SCHEMBL1689138

SCHEMBL1689138

Cc1ccc(-c2nc3nn(-c4ccccc4)cc3c(=O)n2-c2ccc(Cl)cc2)cc1

nearest known ligand 0.53

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 7/20 0.53
TP53 P04637 2/20 0.49
RAB9A P51151 1/20 0.49
NPSR1 Q6W5P4 1/20 0.49
MAPT P10636 4/20 0.48
MDM2 Q00987 1/20 0.47
LMNA P02545 1/20 0.47
GAA P10253 1/20 0.47
AURKA O14965 1/20 0.46
CNR1 P21554 2/20 0.46
CNR2 P34972 2/20 0.46
GPR55 Q9Y2T6 2/20 0.46
CCNE1 P24864 2/20 0.44
CDK2 P24941 2/20 0.44
RXFP1 Q9HBX9 1/20 0.44
PTGS2 P35354 1/20 0.44
GRM5 P41594 1/20 0.44
GRM1 Q13255 1/20 0.44
MEN1 O00255 1/20 0.44
HSP90AA1 P07900 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1689094 0.99 ALDH1A1 (0.52) ALDH1A1TP53RAB9ANPSR1MAPT
SCHEMBL1689243 0.93 MAPT (0.51) ALDH1A1TP53MAPTGAACNR1
SCHEMBL5611687 0.91 MAPT (0.52) ALDH1A1MAPTMDM2GAACNR1
SCHEMBL5611548 0.90 TP53 (0.61) ALDH1A1TP53RAB9ANPSR1MAPT
SCHEMBL1688969 0.90 MAPT (0.49) ALDH1A1MAPTAURKACNR1CNR2
SCHEMBL5611531 0.90 TP53 (0.46) ALDH1A1TP53MAPTMDM2LMNA
SCHEMBL1689182 0.90 MAPT (0.43) ALDH1A1TP53RAB9ANPSR1MAPT
SCHEMBL1689133 0.90 MAPT (0.58) ALDH1A1TP53RAB9ANPSR1MAPT
SCHEMBL1689306 0.89 POLB (0.46) ALDH1A1MAPTLMNAAURKACNR1
SCHEMBL5611868 0.89 ALDH1A1 (0.51) ALDH1A1TP53RAB9ANPSR1MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1807429-A2 COMPOUNDS AND COMPOSITIONS AS INHIBITORS OF CANNABINOID RECEPTOR 1 ACTIVITY IRM, LLC (BM) 2007-07-18 EP claimed
WO-2006047516-A2 COMPOUNDS AND COMPOSITIONS AS INHIBITORS OF CANNABINOID RECEPTOR 1 ACTIVITY IRM LLC (BM) 2006-05-04 WO claimed
EP-1807429-A2 COMPOUNDS AND COMPOSITIONS AS INHIBITORS OF CANNABINOID RECEPTOR 1 ACTIVITY IRM, LLC (BM) 2007-07-18 EP disclosed
WO-2006047516-A2 COMPOUNDS AND COMPOSITIONS AS INHIBITORS OF CANNABINOID RECEPTOR 1 ACTIVITY IRM LLC (BM) 2006-05-04 WO disclosed