Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.35 |
| ▸ | EPHX2 | P34913 | 4/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.32 |
| ▸ | GAA | P10253 | 2/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | RECQL | P46063 | 1/20 | 0.32 |
| ▸ | CASP6 | P55212 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | ELAVL1 | Q15717 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.32 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.32 |
| ▸ | DRD2 | P14416 | 1/20 | 0.32 |
| ▸ | DRD4 | P21917 | 1/20 | 0.32 |
| ▸ | DRD3 | P35462 | 1/20 | 0.32 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9335346 | 0.91 | PTGDR2 (0.32) | PTGDR2EPHX2L3MBTL1GAAMAPT | |
| SCHEMBL10431891 | 0.91 | PTGDR2 (0.32) | PTGDR2EPHX2L3MBTL1GAAMAPT | |
| SCHEMBL9101971 | 0.89 | PTGDR2 (0.39) | PTGDR2EPHX2L3MBTL1GAAMAPT | |
| SCHEMBL5278348 | 0.86 | PTGDR2 (0.47) | PTGDR2EPHX2MAPTMEN1ALDH1A1 | |
| SCHEMBL30764027 | 0.86 | PTGDR2 (0.43) | PTGDR2EPHX2L3MBTL1CHRNB2CHRNA4 | |
| SCHEMBL2217850 | 0.84 | PTGDR2 (0.46) | PTGDR2EPHX2MAPTMEN1ALDH1A1 | |
| SCHEMBL361128 | 0.84 | PTGDR2 (0.49) | PTGDR2EPHX2GAAMAPTMEN1 | |
| SCHEMBL3387056 | 0.83 | PTGDR2 (0.36) | PTGDR2EPHX2L3MBTL1GAAMAPT | |
| SCHEMBL16712212 | 0.82 | CHRNB2 (0.43) | PTGDR2EPHX2L3MBTL1GAAMAPT | |
| SCHEMBL28966936 | 0.82 | HTR6 (0.44) | MEN1ALDH1A1KMT2ACYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240368161-A1 | CYCLOPROPANECARBOXAMIDE-CONTAINING COMPOUNDS AND APPLICATION THEREOF | CGENETECH (SUZHOU,CHINA) CO., LTD. (CN) | 2024-11-07 | — | — | US | disclosed |
| EP-4446322-A1 | CYCLOPROPANAMIDE-CONTAINING COMPOUND AND USE THEREOF | CGeneTech (Suzhou, China) Co., Ltd. (CN) | 2024-10-16 | — | — | EP | disclosed |
| CN-116496268-A | Cyclopropylamide-containing compound and application thereof | 盛世泰科生物医药技术(苏州)有限公司 | 2023-07-28 | — | — | CN | disclosed |
| WO-2023138550-A1 | CYCLOPROPANAMIDE-CONTAINING COMPOUND AND USE THEREOF | 盛世泰科生物医药技术(苏州)有限公司 | 2023-07-27 | — | — | WO | disclosed |
| EP-2894151-B1 | IMIDAZOLINE DERIVATIVES, PREPARATION METHODS THEREOF, AND THEIR APPLICATIONS IN MEDICINE | Shanghai hengrui pharmaceutical co ltd (CN) | 2020-11-11 | — | — | EP | disclosed |
| EP-3423446-B1 | NEW 2-SUBSTITUTED INDAZOLES, METHODS FOR PRODUCING SAME, PHARMACEUTICAL PREPARATIONS THAT CONTAIN SAME, AND USE OF SAME TO PRODUCE DRUGS | Bayer Pharma AG (DE) | 2020-09-16 | — | — | EP | disclosed |
| CN-111032641-A | Substituted 5-cyanoindole compounds and uses thereof | 诺华股份有限公司 | 2020-04-17 | — | — | CN | disclosed |
| EP-3423446-A1 | NEW 2-SUBSTITUTED INDAZOLES, METHODS FOR PRODUCING SAME, PHARMACEUTICAL PREPARATIONS THAT CONTAIN SAME, AND USE OF SAME TO PRODUCE DRUGS | Bayer Pharma Aktiengesellschaft (DE) | 2019-01-09 | — | — | EP | disclosed |
| US-9895355-B2 | Methods of treating androgen receptor-mediated disorders with imidazoline derivatives | Shanghai Hengru Pharmaceutical Co., Ltd. (CN) | 2018-02-20 | — | — | US | disclosed |
| US-20170128422-A1 | METHODS OF TREATING ANDROGEN RECEPTOR-MEDIATED DISORDERS WITH IMIDAZOLINE DERIVATIVES | Shanghai hengrui pharmaceutical co ltd (CN) | 2017-05-11 | — | — | US | disclosed |
| US-9586947-B2 | Imidazoline derivatives, preparation methods thereof, and their applications in medicine | SHANGHAI HENGRUI PHARMACEUTICAL CO., LTD. (CN) | 2017-03-07 | — | — | US | disclosed |
| US-20150225381-A1 | IMIDAZOLINE DERIVATIVES, PREPARATION METHODS THEREOF, AND THEIR APPLICATIONS IN MEDICINE | JIANGSU HENGRUI MEDICINE CO., LTD. (CN) | 2015-08-13 | — | — | US | disclosed |
| EP-2894151-A1 | IMIDAZOLINE DERIVATIVES, PREPARATION METHODS THEREOF, AND THEIR APPLICATIONS IN MEDICINE | Shanghai Hengrui Pharmaceutical Co. Ltd. (CN) | 2015-07-15 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240368161-A1 | CYCLOPROPANECARBOXAMIDE-CONTAINING COMPOUNDS AND APPLICATION THEREOF | MCL1, BCL9, BCL9L | PTGDR2 45/4885EPHX2 275/4885L3MBTL1 4722/4885 |
| US-20170128422-A1 | METHODS OF TREATING ANDROGEN RECEPTOR-MEDIATED DISORDERS WITH IMIDAZOLINE DERIVATIVES | NR5A1, ESRRA, ESRRB | PTGDR2 194/4885EPHX2 4259/4885L3MBTL1 4064/4885 |
| US-20150225381-A1 | IMIDAZOLINE DERIVATIVES, PREPARATION METHODS THEREOF, AND THEIR APPLICATIONS IN MEDICINE | AR, KLK3, NR5A1 | PTGDR2 136/4885EPHX2 3678/4885L3MBTL1 4881/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.