SCHEMBL1689321

SCHEMBL1689321

CCc1ccc(-c2nc3c(nc(-c4ccc(Br)cc4)n3-c3ccccc3)c(=O)[nH]2)cc1

nearest known ligand 0.65

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
DHFR P00374 6/20 0.65
TNKS O95271 3/20 0.44
TNKS2 Q9H2K2 3/20 0.44
CYP1A1 P04798 1/20 0.44
CYP1B1 Q16678 1/20 0.44
PARP2 Q9UGN5 2/20 0.43
MAPT P10636 2/20 0.42
KDM4E B2RXH2 1/20 0.42
ADORA2B P29275 1/20 0.40
ALDH1A1 P00352 1/20 0.40
LMNA P02545 1/20 0.40
HTT P42858 1/20 0.40
BLM P54132 1/20 0.40
PLEC Q15149 1/20 0.40
SMN1; SMN2 Q16637 1/20 0.40
KHK P50053 1/20 0.39
TDP2 O95551 1/20 0.39
POLB P06746 1/20 0.39
PDE5A O76074 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5611707 0.89 DHFR (0.70) DHFRTNKSTNKS2CYP1A1CYP1B1
SCHEMBL1688958 0.85 DHFR (0.65) DHFRTNKSTNKS2CYP1A1CYP1B1
SCHEMBL4510952 0.83 DHFR (0.65) DHFRTNKSTNKS2CYP1A1CYP1B1
SCHEMBL1689319 0.82 DHFR (0.62) DHFRTNKSTNKS2CYP1A1CYP1B1
SCHEMBL5611463 0.80 DHFR (0.64) DHFRTNKSTNKS2CYP1A1CYP1B1
SCHEMBL5611631 0.80 DHFR (0.66) DHFRTNKSTNKS2CYP1A1CYP1B1
SCHEMBL5612000 0.79 DHFR (0.52) DHFRTNKSTNKS2PARP2MAPT
SCHEMBL1689041 0.78 DHFR (0.60) DHFRTNKSTNKS2CYP1A1CYP1B1
SCHEMBL5611867 0.78 DHFR (0.62) DHFRTNKSTNKS2CYP1A1CYP1B1
SCHEMBL5611811 0.77 DHFR (0.61) DHFRMAPTKDM4EALDH1A1LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1807429-A2 COMPOUNDS AND COMPOSITIONS AS INHIBITORS OF CANNABINOID RECEPTOR 1 ACTIVITY IRM, LLC (BM) 2007-07-18 EP claimed
WO-2006047516-A2 COMPOUNDS AND COMPOSITIONS AS INHIBITORS OF CANNABINOID RECEPTOR 1 ACTIVITY IRM LLC (BM) 2006-05-04 WO claimed