Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 3/20 | 0.63 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.63 |
| ▸ | GRM5 | P41594 | 1/20 | 0.57 |
| ▸ | MAPT | P10636 | 7/20 | 0.56 |
| ▸ | LMNA | P02545 | 4/20 | 0.56 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.56 |
| ▸ | MITF | O75030 | 1/20 | 0.56 |
| ▸ | CCR6 | P51684 | 1/20 | 0.56 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.56 |
| ▸ | MEN1 | O00255 | 2/20 | 0.54 |
| ▸ | GAA | P10253 | 2/20 | 0.54 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.52 |
| ▸ | FAAH | O00519 | 1/20 | 0.52 |
| ▸ | MGLL | Q99685 | 1/20 | 0.52 |
| ▸ | ENPP2 | Q13822 | 4/20 | 0.51 |
| ▸ | DRD4 | P21917 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1274938 | 0.91 | HTT (0.73) | HTTKMT2AGRM5MAPTLMNA | |
| SCHEMBL29937743 | 0.84 | CTSB (0.65) | HTTKMT2AGRM5MAPTLMNA | |
| SCHEMBL7118705 | 0.84 | HTT (0.64) | HTTKMT2AGRM5MAPTLMNA | |
| SCHEMBL3799173 | 0.84 | CTSB (0.65) | HTTKMT2AGRM5MAPTLMNA | |
| SCHEMBL3064690 | 0.83 | HTT (0.68) | HTTKMT2AGRM5MAPTLMNA | |
| SCHEMBL29426374 | 0.83 | HTT (0.68) | HTTKMT2AGRM5MAPTLMNA | |
| SCHEMBL13790192 | 0.83 | HTT (0.63) | HTTKMT2AGRM5MAPTLMNA | |
| SCHEMBL29738367 | 0.82 | GAA (0.63) | HTTKMT2AMAPTLMNAL3MBTL1 | |
| SCHEMBL3292356 | 0.82 | GAA (0.63) | HTTKMT2AMAPTLMNAL3MBTL1 | |
| SCHEMBL4526192 | 0.82 | GRM5 (0.67) | HTTKMT2AGRM5MAPTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015107057-A1 | SYNTHESIS OF VORTIOXETINE VIA (2-(PIPERAZINE-1 -YL)PHENYL)ANILINE INTERMEDIATES | LEK PHARMACEUTICALS D.D. (SI) | 2015-07-23 | — | — | WO | disclosed |
| EP-2894154-A1 | Synthesis of vortioxetine via (2-(piperazine-1-yl)phenyl)aniline intermediates | LEK Pharmaceuticals d.d. (SI) | 2015-07-15 | — | — | EP | disclosed |