Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CARM1 | Q86X55 | 3/20 | 0.49 |
| ▸ | PRMT6 | Q96LA8 | 3/20 | 0.49 |
| ▸ | USP28 | Q96RU2 | 1/20 | 0.48 |
| ▸ | USP25 | Q9UHP3 | 1/20 | 0.48 |
| ▸ | CETP | P11597 | 4/20 | 0.48 |
| ▸ | GLS | O94925 | 1/20 | 0.48 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.47 |
| ▸ | CNR1 | P21554 | 2/20 | 0.47 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.47 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.47 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.46 |
| ▸ | VNN1 | O95497 | 1/20 | 0.45 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.44 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | KDM5A | P29375 | 1/20 | 0.43 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.43 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20776850 | 0.82 | CARM1 (0.51) | CARM1PRMT6USP28USP25CETP | |
| SCHEMBL14966127 | 0.82 | USP28 (0.62) | CARM1PRMT6USP28USP25CETP | |
| SCHEMBL1416997 | 0.82 | CETP (0.56) | CETPCHRM2CNR1CHRM1CHRM3 | |
| SCHEMBL14966126 | 0.81 | CETP (0.52) | CARM1PRMT6CETPCHRM2CHRM1 | |
| SCHEMBL169091 | 0.80 | CETP (0.49) | CARM1PRMT6CETPCHRM2CHRM1 | |
| SCHEMBL9902980 | 0.79 | CHRM2 (0.50) | CARM1PRMT6USP28USP25CETP | |
| SCHEMBL12963217 | 0.79 | CHRM2 (0.51) | CARM1PRMT6USP28USP25CETP | |
| SCHEMBL3285226 | 0.78 | CETP (0.65) | CETPMAPK14ROCK2ROCK1 | |
| SCHEMBL4598244 | 0.78 | CHRM2 (0.54) | CARM1PRMT6USP28USP25CETP | |
| SCHEMBL16268378 | 0.78 | CARM1 (0.48) | CARM1PRMT6USP28USP25CETP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2611441-A1 | BACE INHIBITORS FOR USE IN THE TREATMENT OF DIABETES | F.HOFFMANN-LA ROCHE AG (CH) | 2013-07-10 | — | — | EP | disclosed |
| WO-2012028563-A1 | BACE INHIBITORS FOR USE IN THE TREATMENT OF DIABETES | F. HOFFMANN-LA ROCHE AG (CH) | 2012-03-08 | — | — | WO | disclosed |