Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 | P08172 | 3/20 | 0.54 |
| ▸ | USP28 | Q96RU2 | 1/20 | 0.53 |
| ▸ | USP25 | Q9UHP3 | 1/20 | 0.53 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.48 |
| ▸ | SCN8A | Q9UQD0 | 2/20 | 0.47 |
| ▸ | BCHE | P06276 | 1/20 | 0.46 |
| ▸ | CARM1 | Q86X55 | 2/20 | 0.46 |
| ▸ | PRMT6 | Q96LA8 | 2/20 | 0.46 |
| ▸ | CNR1 | P21554 | 1/20 | 0.46 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.46 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.46 |
| ▸ | KDM5A | P29375 | 1/20 | 0.45 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.45 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.45 |
| ▸ | CETP | P11597 | 2/20 | 0.44 |
| ▸ | GLS | O94925 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.43 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14966127 | 0.90 | USP28 (0.62) | CHRM2USP28USP25MAPK14SCN8A | |
| SCHEMBL9902980 | 0.84 | CHRM2 (0.50) | CHRM2USP28USP25MAPK14SCN8A | |
| SCHEMBL3351531 | 0.81 | MAPK14 (0.50) | CHRM2USP28USP25MAPK14SCN8A | |
| SCHEMBL20776850 | 0.81 | CARM1 (0.51) | CHRM2USP28USP25MAPK14SCN8A | |
| SCHEMBL4575197 | 0.81 | BCHE (0.53) | CHRM2USP28USP25MAPK14SCN8A | |
| SCHEMBL9882943 | 0.80 | SIGMAR1 (0.49) | CHRM2USP28USP25MAPK14SCN8A | |
| SCHEMBL79435 | 0.79 | CHRM2 (0.52) | CHRM2USP28USP25MAPK14CNR1 | |
| Hydrochloric Acid SCHEMBL8514570 | 0.79 | SIGMAR1 (0.48) | CHRM2USP28USP25MAPK14SCN8A | |
| SCHEMBL169092 | 0.78 | CARM1 (0.49) | CHRM2USP28USP25MAPK14CARM1 | |
| SCHEMBL9882938 | 0.78 | SIGMAR1 (0.53) | CHRM2USP28USP25MAPK14SCN8A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008065500-A2 | HETEROARYL AMIDES AS TYPE I GLYCINE TRANSPORT INHIBITORS | PFIZER PRODUCTS INC. (US) | 2008-06-05 | — | — | WO | disclosed |