Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 8/20 | 0.47 |
| ▸ | THRA | P10827 | 3/20 | 0.47 |
| ▸ | THRB | P10828 | 3/20 | 0.47 |
| ▸ | CYP2J2 | P51589 | 1/20 | 0.46 |
| ▸ | PTPN1 | P18031 | 5/20 | 0.44 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | CYP4A11 | Q02928 | 2/20 | 0.41 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.40 |
| ▸ | HAO1 | Q9UJM8 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL168852 | 0.90 | GSK3B (0.50) | GSK3BTHRATHRBCYP2J2PTPN1 | |
| SCHEMBL168135 | 0.83 | HSD17B10 (0.59) | CYP2J2TNKS2LMNAHSD17B10CYP4A11 | |
| SCHEMBL3935835 | 0.81 | THRA (0.47) | GSK3BTHRATHRBPTPN1CYP4A11 | |
| SCHEMBL23929839 | 0.79 | GSK3B (0.57) | GSK3BTHRATHRBPTPN1 | |
| SCHEMBL4303524 | 0.79 | PTPRC (0.46) | THRATHRBCYP2J2PTPN1TNKS2 | |
| SCHEMBL12065158 | 0.79 | THRA (0.61) | GSK3BTHRATHRBCYP2J2TNKS2 | |
| SCHEMBL9251076 | 0.79 | HSD17B10 (0.57) | THRATHRBTNKS2LMNAHSD17B10 | |
| SCHEMBL12020282 | 0.79 | PLOD2 (0.51) | THRATHRBCYP2J2TNKS2LMNA | |
| SCHEMBL16672630 | 0.78 | CTDSP1 (0.55) | TNKS2LMNA | |
| SCHEMBL3011724 | 0.78 | THRA (0.66) | GSK3BTHRATHRBPTPN1HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012027965-A1 | NOVEL COMPOUNDS | GLAXO GROUP LIMITED (GB) | 2012-03-08 | — | — | WO | disclosed |