Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 1/20 | 0.38 |
| ▸ | DGAT1 | O75907 | 3/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | RAD52 | P43351 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 3/20 | 0.32 |
| ▸ | GAA | P10253 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | PKM | P14618 | 1/20 | 0.32 |
| ▸ | MGAM | O43451 | 1/20 | 0.32 |
| ▸ | SI | P14410 | 1/20 | 0.32 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | ELANE | P08246 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16920147 | 0.87 | PPARG (0.39) | PPARGDGAT1NPC1PLA2G2AHTT | |
| SCHEMBL16922680 | 0.83 | FLT3 (0.34) | DGAT1HTTMAPTGAAKDM4E | |
| SCHEMBL16920140 | 0.78 | NPC1 (0.43) | DGAT1NPC1SMN1; SMN2PLA2G2AHTT | |
| SCHEMBL16920142 | 0.70 | DGAT1 (0.46) | DGAT1NPC1MAPTLMNA | |
| SCHEMBL16922678 | 0.67 | ATM (0.43) | NPC1SMN1; SMN2HTTKMT2AMAPT | |
| SCHEMBL30363805 | 0.66 | PPARG (0.40) | PPARGDGAT1NPC1SMN1; SMN2HTT | |
| SCHEMBL30363639 | 0.64 | AAK1 (0.42) | PPARGDGAT1SMN1; SMN2HTTMAPT | |
| SCHEMBL6182357 | 0.62 | AAK1 (0.50) | NPC1SMN1; SMN2HTTMEN1KMT2A | |
| SCHEMBL17963471 | 0.62 | DGAT1 (0.44) | DGAT1NPC1SMN1; SMN2HTTMEN1 | |
| SCHEMBL14709937 | 0.61 | NPC1 (0.48) | NPC1SMN1; SMN2HTTMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2963013-A1 | INDOLE AND AZAINDOLE DERIVATIVES EACH HAVING AMPK-ACTIVATING ACTIVITY | Shionogi & Co., Ltd. (JP) | 2016-01-06 | — | — | EP | disclosed |
| US-20150203450-A1 | INDOLE AND AZAINDOLE DERIVATIVE HAVING AMPK-ACTIVATING ACTIVITY | SHIONOGI & CO., LTD. (JP) | 2015-07-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150203450-A1 | INDOLE AND AZAINDOLE DERIVATIVE HAVING AMPK-ACTIVATING ACTIVITY | PRKAA1, PRKAA2, PRKAB1 | PPARG 204/4885DGAT1 2045/4885NPC1 2996/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.