⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7848594 | 0.80 | TSHR (0.32) | — | |
| SCHEMBL7853498 | 0.76 | TSHR (0.30) | — | |
| SCHEMBL2659212 | 0.74 | — | — | |
| SCHEMBL170595 | 0.73 | TSHR (0.32) | — | |
| SCHEMBL1840425 | 0.72 | — | — | |
| SCHEMBL27654347 | 0.72 | — | — | |
| SCHEMBL5705224 | 0.72 | — | — | |
| SCHEMBL3191590 | 0.72 | — | — | |
| SCHEMBL27448399 | 0.69 | — | — | |
| SCHEMBL11667238 | 0.68 | ALOX15 (0.32) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 50 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4215182-A1 | DIAMINOPYRIMIDINE P2X3 AND P2X2/3 RECEPTOR MODULATORS FOR USE IN THE TREATMENT OF COUGH | Afferent Pharmaceuticals Inc. (US) | 2023-07-26 | — | — | EP | claimed |
| EP-3865134-A1 | METHODS OF USING DIAMINOPYRIMIDINE P2X3 AND P2X 2/3 RECEPTOR MODULATORS FOR TREATMENT OF ACUTE AND SUB-ACUTE COUGH, URGE TO COUGH AND CHRONIC COUGH, IN RESPIRATORY DISEASES | Afferent Pharmaceuticals Inc. (US) | 2021-08-18 | — | — | EP | claimed |
| EP-3355889-A1 | DIAMINOPYRIMIDINE P2X3 AND P2X2/3 RECEPTOR MODULATORS FOR USE IN THE TREATMENT OF COUGH | Afferent Pharmaceuticals Inc. (US) | 2018-08-08 | — | — | EP | claimed |
| EP-3212636-A1 | NEW PYRIDINYLOXY- AND PHENYLOXY-PYRAZOLYL COMPOUNDS | F. Hoffmann-La Roche AG (CH) | 2017-09-06 | — | — | EP | claimed |
| US-20160263112-A1 | SUBSTITUTED PYRIMIDINES FOR TREATMENT OF ACUTE COUGH, CHRONIC COUGH AND URGE TO COUGH | Afferent Pharmaceuticals, Inc. (US) | 2016-09-15 | — | — | US | claimed |
| EP-3035932-A1 | DIAMINOPYRIMIDINE P2X3 AND P2X 2/3 RECEPTOR MODULATORS FOR TREATMENT OF ACUTE, SUB-ACUTE OR CHRONIC COUGH | Afferent Pharmaceuticals Inc. (US) | 2016-06-29 | — | — | EP | claimed |
| WO-2016066664-A1 | NEW PYRIDINYLOXY- AND PHENYLOXY-PYRAZOLYL COMPOUNDS | F. HOFFMANN-LA ROCHE AG (CH) | 2016-05-06 | — | — | WO | claimed |
| WO-2015027212-A1 | DIAMINOPYRIMIDINE P2X3 AND P2X 2/3 RECEPTOR MODULATORS FOR TREATMENT OF ACUTE, SUB-ACUTE OR CHRONIC COUGH | AFFERENT PHARMACEUTICALS INC. (US) | 2015-02-26 | — | — | WO | claimed |
| US-20150057299-A1 | Methods of Using Diaminopyrimidine P2X3 and P2X 2/3 Receptor Modulators for Treatment of Acute and Sub-Acute Cough, Urge to Cough and Chronic Cough, in Respiratory Diseases | Afferent Pharmaceuticals, Inc. | 2015-02-26 | — | — | US | claimed |
| EP-1412343-B1 | COMPOUNDS, WHICH ARE POTENT INHIBITORS OF NA+/CA2+ EXCHANGE MECHANISM AND ARE USEFUL IN THE TREATMENT OF ARRHYTHMIAS | ORION CORP (FI) | 2006-08-30 | — | — | EP | claimed |
| US-20020045758-A1 | Pesticidal 1-arylpyrazoles | RHONE-POULENC INC. | 2002-04-18 | — | — | US | claimed |
| EP-3212636-B1 | NEW PYRIDINYLOXY- AND PHENYLOXY-PYRAZOLYL COMPOUNDS | HOFFMANN LA ROCHE (CH) | 2023-11-29 | — | — | EP | disclosed |
| EP-4215182-A1 | DIAMINOPYRIMIDINE P2X3 AND P2X2/3 RECEPTOR MODULATORS FOR USE IN THE TREATMENT OF COUGH | Afferent Pharmaceuticals Inc. (US) | 2023-07-26 | — | — | EP | disclosed |
| US-20220143015-A1 | DIAMINOPYRIMIDINE P2X3 AND P2X2/3 RECEPTOR MODULATORS FOR USE IN THE TREATMENT OF COUGH | Afferent Pharmaceuticals, Inc. (US) | 2022-05-12 | — | — | US | disclosed |
| EP-3981406-A1 | METHODS AND COMPOSITIONS FOR TREATING DISEASES AND CONDITIONS | Afferent Pharmaceuticals Inc. (US) | 2022-04-13 | — | — | EP | disclosed |
| WO-2005113552-A1 | SUBSTITUTED AZACHINAZOLINES HAVING AN ANTIVIRAL ACTION | BAYER HEALTHCARE AG (DE) | 2005-12-01 | — | — | WO | disclosed |
| WO-2005047294-A1 | MACROCYCLIC KINASE INHIBITORS | ABBOTT LABORATORIES (US) | 2005-05-26 | — | — | WO | disclosed |
| WO-2004096778-A1 | SUBSTITUTED DIHYDROCHINAZOLINES HAVING ANTIVIRAL PROPERTIES | BAYER HEALTHCARE AG (DE) | 2004-11-11 | — | — | WO | disclosed |
| US-4182733-A | REACTING PHOSPHORIC ACID ESTER WITH HALOGENATING AGENT AND AN OLEFIN | BAYER AKTIENGESELLSCHAFT (DE) | 1980-01-08 | — | — | US | disclosed |
| US-4138452-A | INTERMEDIATES FOR INSECTICIDES AND FLAMEPROOFING AGENTS | BAYER AKTIENGESELLSCHAFT (DE) | 1979-02-06 | — | — | US | disclosed |