Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKT1 | P31749 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | RAB9A | P51151 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.33 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.33 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.33 |
| ▸ | SYK | P43405 | 1/20 | 0.33 |
| ▸ | KYAT1 | Q16773 | 1/20 | 0.33 |
| ▸ | ABCC9 | O60706 | 1/20 | 0.33 |
| ▸ | KCNJ11 | Q14654 | 1/20 | 0.33 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.32 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.32 |
| ▸ | RELA | Q04206 | 1/20 | 0.32 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16011812 | 0.76 | SMN1; SMN2 (0.48) | MAPTRAB9ASMN1; SMN2POLB | |
| SCHEMBL17060879 | 0.73 | JAK2 (0.38) | SYKCYP17A1 | |
| SCHEMBL23545662 | 0.73 | HDAC1 (0.48) | AKT1NPC1HSD17B10HDAC3HDAC1 | |
| SCHEMBL17572258 | 0.72 | FPR3 (0.43) | RAB9AKDM4E | |
| SCHEMBL17572297 | 0.72 | GAA (0.42) | MAPTRAB9AKDM4ENPC1 | |
| SCHEMBL7032556 | 0.72 | CA12 (0.38) | RAB9AHDAC1TRPV1 | |
| SCHEMBL24051939 | 0.71 | HDAC3 (0.42) | SMN1; SMN2HDAC3HDAC1HDAC2NCOR2 | |
| SCHEMBL15669149 | 0.71 | CA14 (0.36) | AKT1MAPTRAB9AKDM4ENPC1 | |
| SCHEMBL5360319 | 0.70 | MT-CO2 (0.37) | AKT1MAPTRAB9AKDM4ENPC1 | |
| SCHEMBL718380 | 0.70 | CYP17A1 (0.52) | SMN1; SMN2CYP17A1TRPV1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3096751-A1 | 12-EPI-PLEUROMUTILINS | Nabriva Therapeutics AG (AT) | 2016-11-30 | — | — | EP | disclosed |
| WO-2015110481-A1 | 12-EPI-PLEUROMUTILINS | NABRIVA THERAPEUTICS AG (AT) | 2015-07-30 | — | — | WO | disclosed |