Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 2/20 | 0.46 |
| ▸ | PDE9A | O76083 | 1/20 | 0.37 |
| ▸ | DHFR | P00374 | 1/20 | 0.36 |
| ▸ | DCPS | Q96C86 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | OPRL1 | P41146 | 3/20 | 0.35 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.35 |
| ▸ | KCNH3 | Q9ULD8 | 1/20 | 0.34 |
| ▸ | BRS3 | P32247 | 1/20 | 0.34 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.33 |
| ▸ | GCK | P35557 | 1/20 | 0.33 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | CNR1 | P21554 | 1/20 | 0.32 |
| ▸ | CNR2 | P34972 | 1/20 | 0.32 |
| ▸ | HTR5A | P47898 | 1/20 | 0.32 |
| ▸ | KDM1A | O60341 | 1/20 | 0.32 |
| ▸ | MAOA | P21397 | 1/20 | 0.32 |
| ▸ | MAOB | P27338 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1220398 | 0.84 | MAP4K4 (0.37) | MAP4K4NPC1RAB9A | |
| SCHEMBL3209605 | 0.80 | RAB9A (0.41) | TSHRBRS3MAP4K4NPC1RAB9A | |
| SCHEMBL3197095 | 0.78 | RAB9A (0.44) | TSHRMAP4K4NPC1RAB9A | |
| SCHEMBL28265964 | 0.78 | MAP4K4 (0.32) | MAPK1MAP4K4 | |
| SCHEMBL20385485 | 0.77 | SMN1; SMN2 (0.43) | MAPK1PDE9AHIF1A | |
| SCHEMBL30629342 | 0.77 | MCHR1 (0.39) | MAPK1DHFRDCPSTSHRKCNH3 | |
| SCHEMBL24011306 | 0.75 | MAP4K4 (0.36) | MAP4K4 | |
| SCHEMBL5688150 | 0.75 | GBA1 (0.52) | KDM1A | |
| SCHEMBL29601250 | 0.73 | ALOX5AP (0.40) | MAPK1OPRL1GCKKDM1AMAOA | |
| SCHEMBL12466143 | 0.73 | KDM1A (0.40) | MAPK1DHFRDCPSOPRL1CNR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109153650-A | Amine-substituted aryl or heteroaryl compounds as EHMT1 and EHMT2 inhibitors | EPIZYME股份有限公司 | 2019-01-04 | — | — | CN | disclosed |
| WO-2010097379-A1 | SUBSTITUTED PYRIMIDIN DERIVATIVES AND THEIR MEDICAL USE | NEUROSEARCH A/S (DK) | 2010-09-02 | — | — | WO | disclosed |
| WO-2010097379-A1 | SUBSTITUTED PYRIMIDIN DERIVATIVES AND THEIR MEDICAL USE | NEUROSEARCH A/S (DK) | 2010-09-02 | — | — | WO | disclosed |