Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K4 | O95819 | 2/20 | 0.36 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.33 |
| ▸ | JAK2 | O60674 | 1/20 | 0.32 |
| ▸ | JAK1 | P23458 | 1/20 | 0.32 |
| ▸ | JAK3 | P52333 | 1/20 | 0.32 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.32 |
| ▸ | AXL | P30530 | 1/20 | 0.32 |
| ▸ | FLT3 | P36888 | 1/20 | 0.32 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.32 |
| ▸ | MERTK | Q12866 | 1/20 | 0.32 |
| ▸ | GAS6 | Q14393 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.31 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.31 |
| ▸ | CSNK1A1 | P48729 | 2/20 | 0.30 |
| ▸ | CDK7 | P50613 | 2/20 | 0.30 |
| ▸ | CDK9 | P50750 | 2/20 | 0.30 |
| ▸ | CCNK | O75909 | 1/20 | 0.30 |
| ▸ | CDK13 | Q14004 | 1/20 | 0.30 |
| ▸ | CDK12 | Q9NYV4 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1220398 | 0.89 | MAP4K4 (0.37) | MAP4K4JAK2JAK1JAK3 | |
| SCHEMBL3209605 | 0.80 | RAB9A (0.41) | MAP4K4 | |
| SCHEMBL3197095 | 0.78 | RAB9A (0.44) | MAP4K4 | |
| SCHEMBL803404 | 0.76 | PDE2A (0.34) | MAP4K4JAK2JAK1JAK3 | |
| SCHEMBL5688150 | 0.75 | GBA1 (0.52) | JAK2JAK1 | |
| SCHEMBL1693802 | 0.75 | MAPK1 (0.46) | MAP4K4 | |
| SCHEMBL26764897 | 0.75 | MAP4K4 (0.32) | MAP4K4 | |
| SCHEMBL20064079 | 0.73 | CPB1 (0.32) | MERTKMAPK8 | |
| SCHEMBL13162857 | 0.72 | HRH3 (0.47) | MAP4K4 | |
| SCHEMBL13439162 | 0.71 | PAK4 (0.48) | AXLFLT3TYRO3MERTKGAS6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021226276-A2 | NAMPT MODULATORS | CYTOKINETICS, INC. (US) | 2021-11-11 | — | — | WO | disclosed |