Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 3/20 | 0.50 |
| ▸ | MAOB | P27338 | 3/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.42 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | PNMT | P11086 | 1/20 | 0.40 |
| ▸ | CD44 | P16070 | 1/20 | 0.40 |
| ▸ | TMPRSS2 | O15393 | 1/20 | 0.40 |
| ▸ | HTR1A | P08908 | 1/20 | 0.40 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | HTR2C | P28335 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23310922 | 0.73 | HSD17B3 (0.52) | MAOAMAOBTSHRALDH1A1MEN1 | |
| SCHEMBL6261159 | 0.69 | MAOA (0.44) | MAOAMAOBTSHRNOTUMRXFP1 | |
| SCHEMBL130712 | 0.69 | MAOA (0.71) | MAOAMAOBNOTUMRXFP1ALDH1A1 | |
| SCHEMBL1373794 | 0.69 | KMT2A (0.46) | MAOAMAOBTSHRNOTUMRXFP1 | |
| SCHEMBL3402653 | 0.69 | NOTUM (0.48) | MAOAMAOBTSHRNOTUMRXFP1 | |
| SCHEMBL13088965 | 0.69 | MAOA (0.44) | MAOAMAOBTSHRNOTUMRXFP1 | |
| SCHEMBL14573056 | 0.69 | MAOA (0.56) | MAOAMAOBNOTUMRXFP1ALDH1A1 | |
| SCHEMBL3599815 | 0.69 | NOTUM (0.48) | MAOAMAOBNOTUMRXFP1ALDH1A1 | |
| SCHEMBL11983592 | 0.69 | NOTUM (0.48) | MAOAMAOBTSHRNOTUMRXFP1 | |
| SCHEMBL5809499 | 0.69 | MAOA (0.44) | MAOAMAOBTSHRNOTUMRXFP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2379525-B1 | CYCLIC PYRIMIDIN-4-CARBOXAMIDES AS CCR2 RECEPTOR ANTAGONISTS FOR TREATMENT OF INFLAMMATION, ASTHMA AND COPD | BOEHRINGER INGELHEIM INT (DE) | 2015-07-29 | — | — | EP | disclosed |