Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 3/20 | 0.49 |
| ▸ | JAK1 | P23458 | 3/20 | 0.49 |
| ▸ | TYK2 | P29597 | 2/20 | 0.49 |
| ▸ | JAK3 | P52333 | 2/20 | 0.49 |
| ▸ | BCL9 | O00512 | 6/20 | 0.45 |
| ▸ | CTNNB1 | P35222 | 6/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.45 |
| ▸ | NPC1 | O15118 | 2/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.43 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13490610 | 0.86 | BCL9 (0.52) | JAK2JAK1TYK2JAK3BCL9 | |
| SCHEMBL13490607 | 0.85 | JAK2 (0.48) | JAK2JAK1TYK2JAK3BCL9 | |
| SCHEMBL13490731 | 0.83 | ALDH1A1 (0.47) | SMN1; SMN2CYP2C19 | |
| SCHEMBL13490730 | 0.82 | JAK2 (0.50) | JAK2JAK1TYK2JAK3BCL9 | |
| SCHEMBL171665 | 0.82 | JAK2 (0.52) | JAK2JAK1TYK2JAK3BCL9 | |
| SCHEMBL14544157 | 0.82 | JAK2 (0.50) | JAK2JAK1TYK2JAK3BCL9 | |
| SCHEMBL13490506 | 0.81 | JAK2 (0.55) | JAK2JAK1TYK2JAK3SMN1; SMN2 | |
| SCHEMBL171606 | 0.80 | JAK2 (0.49) | JAK2JAK1TYK2JAK3BCL9 | |
| SCHEMBL13490606 | 0.79 | JAK2 (0.46) | JAK2JAK1TYK2JAK3BCL9 | |
| SCHEMBL19405091 | 0.79 | SMN1; SMN2 (0.52) | JAK2JAK1TYK2JAK3SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2426120-A1 | Pyridyltetrahydropyridines and pyridylpiperidines, and method of manufacturing them | Fujifilm Finechemicals Co., Ltd. (JP) | 2012-03-07 | — | — | EP | disclosed |
| US-7632950-B2 | Pyridyltetrahydropyridines and pyridylpiperidines and method of manufacturing them | FUJIFILM FINECHEMICALS CO., LTD (JP) | 2009-12-15 | — | — | US | disclosed |