SCHEMBL169499

SCHEMBL169499

CCN(CC)c1ccc(-c2nnc(-c3ccc(N(C)C)cc3)o2)cc1

nearest known ligand 0.65

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
APP P05067 3/20 0.65
ALDH1A1 P00352 8/20 0.61
KDM4E B2RXH2 7/20 0.61
MAPT P10636 5/20 0.61
HPGD P15428 4/20 0.61
HSD17B10 Q99714 1/20 0.61
NPC1 O15118 9/20 0.56
RAB9A P51151 8/20 0.56
KMT2A Q03164 4/20 0.56
CA1 P00915 1/20 0.56
CA2 P00918 1/20 0.56
SMN1; SMN2 Q16637 4/20 0.55
MEN1 O00255 3/20 0.55
RXFP1 Q9HBX9 2/20 0.55
HCRTR1 O43613 1/20 0.55
GAA P10253 1/20 0.55
NFKB1 P19838 1/20 0.55
CASP3 P42574 1/20 0.55
NFKB2 Q00653 1/20 0.55
RELA Q04206 1/20 0.55

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL131376 0.93 APP (0.53) APPALDH1A1KDM4EMAPTHPGD
SCHEMBL10806984 0.92 APP (0.56) APPALDH1A1KDM4EMAPTHPGD
SCHEMBL12826704 0.91 NPC1 (0.56) APPALDH1A1KDM4EMAPTHPGD
SCHEMBL122784 0.87 APP (0.81) APPALDH1A1KDM4EMAPTHPGD
SCHEMBL10402333 0.86 NPC1 (0.59) APPALDH1A1KDM4EMAPTHPGD
SCHEMBL8889974 0.85 APP (0.79) APPALDH1A1KDM4EMAPTHPGD
SCHEMBL12313134 0.83 NPC1 (0.53) APPALDH1A1KDM4EMAPTHPGD
SCHEMBL8925548 0.83 MAPT (0.50) APPALDH1A1KDM4EMAPTHPGD
SCHEMBL8925543 0.83 MAPT (0.50) APPALDH1A1KDM4EMAPTHPGD
SCHEMBL14112951 0.81 APP (0.42) APPALDH1A1KDM4EMAPTHPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 77 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9235146-B2 Photoconductor RICOH COMPANY, LTD. (JP) 2016-01-12 US disclosed
US-9040215-B2 Amine compound, electrophotographic photoconductor, image forming method, image forming apparatus, and process cartridge RICOH COMPANY, LTD. (JP) 2015-05-26 US disclosed
US-9005856-B2 Hydroxygallium porphyrazine derivative mixture and electrophotographic photoconductor RICOH COMPANY, LTD. (JP) 2015-04-14 US disclosed
US-20150079509-A1 PHOTOCONDUCTOR RICOH COMPANY, LTD. (JP) 2015-03-19 US disclosed
US-8889324-B2 Image bearing member, image forming method, image forming apparatus, and process cartridge RICOH COMPANY, LTD. (JP) 2014-11-18 US disclosed
US-8809543-B2 Electrophotographic photoreceptor, electrophotographic image forming method, electrophotographic image forming apparatus, and process cartridge for electrophotographic image forming apparatus RICOH COMPANY, LTD. (JP) 2014-08-19 US disclosed
US-8586270-B2 Electrophotographic photoconductor, electrophotographic method, and electrophotographic apparatus RICOH COMPANY, LTD. (JP) 2013-11-19 US disclosed
US-20130202994-A1 AMINE COMPOUND, ELECTROPHOTOGRAPHIC PHOTOCONDUCTOR, IMAGE FORMING METHOD, IMAGE FORMING APPARATUS, AND PROCESS CARTRIDGE RICOH COMPANY, LTD. (JP) 2013-08-08 US disclosed
US-8380109-B2 Image forming apparatus and process cartridge RICOH COMPANY, LTD. (JP) 2013-02-19 US disclosed
US-8304153-B2 Electrophotographic photoreceptor, electrophotographic image forming method, electrophotographic image forming apparatus, electrophotographic process cartridge RICOH COMPANY, LTD. (JP) 2012-11-06 US disclosed
US-6074792-A CHARGE TRANSPORT LAYER AND CHARGE GENERATING LAYER RICOH COMPANY, LTD. (JP) 2000-06-13 US disclosed
US-6068956-A CONTAINS AS A CHARGE GENERATION MATERIAL A PIGMENT INCLUDING A COMPOUND WITH A TETRAAZAPORPHYRIN SKELETON RICOH COMPANY, LTD. (JP) 2000-05-30 US disclosed
US-6054237-A ELECTROPHOTOGRAPHIC PHOTORECEPTOR WHERE THE CHARGE GENERATING LAYER COMPRISES A TAU-TYPE NONMETALLIC PHTHALOCYANINE HAVING ONE OR MORE PEAKS AT BRAGG'S ANGLE AND COPOLYMERS OF VINYL ACETATE-VINYL CHLORIDE; APPARATUS FOR INVERSION DEVELOPMENT SHARP KABUSHIKI KAISHA (JP) 2000-04-25 US disclosed
US-6030736-A PHOTOCONDUCTOR INCLUDES IN A TOP LAYER THEREOF A POLYSILOXANE MIXTURE SELECTED FROM AN UNMODIFIED POLYSILOXANE COMPOUND AND A MIXTURE OF AN UNMODIFIED POLYSILOXANE COMPOUND AND A METHACRYL OR VINYL OR ALKYL MODIFIED POLYSILOXANE RICOH COMPANY, LTD. (JP) 2000-02-29 US disclosed
US-5981124-A PHOTOCONDUCTIVE LAYER COMPRISES A COMPOUND CONTAINING AN AZO CHARGE GENERATING GROUP, A TRAIARYLAMINO CHARGE TRANSPORTING GROUP AND A BIVALENT COUPLER RICOH COMPANY, LTD. (JP) 1999-11-09 US disclosed
EP-0926557-A1 Electrophotographic photoreceptor, process for producing the same, and image forming apparatus using same Sharp Kabushiki Kaisha (JP) 1999-06-30 EP disclosed
CN-1196506-A Electronic photographic photoreceptor RICOH KK (JP) 1998-10-21 CN disclosed
US-5702855-A Electrophotographic photoconductor containing a mixture of a phenol compound and an organic sulfur-containing compound RICOH COMPANY, LTD. (JP) 1997-12-30 US disclosed
US-5578405-A ELECTROCONDUCTIVE SUPPORT WITH ORGANIC PIGMENT LAYER FOR COPY MACHINE AND PRINTERS RICOH COMPANY (JP) 1996-11-26 US disclosed
US-5474868-A Having electroconductive support and a photoconductive layer containing charge generating material, charge transporting material and lignin; high quality image and excellent ozone resistance RICOH COMPANY, LTD. (JP) 1995-12-12 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20130202994-A1 AMINE COMPOUND, ELECTROPHOTOGRAPHIC PHOTOCONDUCTOR, IMAGE FORMING METHOD, IMAGE FORMING APPARATUS, AND PROCESS CARTRIDGE ARL1, ATXN2L, AHR APP 697/4885ALDH1A1 1094/4885KDM4E 4009/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.