Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGES | O14684 | 3/20 | 0.41 |
| ▸ | PIK3R2 | O00459 | 13/20 | 0.38 |
| ▸ | PIK3CD | O00329 | 9/20 | 0.35 |
| ▸ | PIK3CG | P48736 | 3/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | CASP1 | P29466 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | CTSS | P25774 | 1/20 | 0.35 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1695362 | 0.93 | PIK3R2 (0.41) | PIK3R2PIK3CDPIK3CGKDM4EPOLB | |
| SCHEMBL1695242 | 0.86 | PIK3R2 (0.39) | PIK3R2PIK3CDPIK3CG | |
| SCHEMBL1695135 | 0.85 | PIK3R2 (0.43) | PIK3R2PIK3CDPIK3CG | |
| SCHEMBL1694990 | 0.85 | PTGES (0.38) | PTGESPIK3R2PIK3CDPIK3CGCTSS | |
| SCHEMBL1694949 | 0.84 | PIK3R2 (0.39) | PIK3R2PIK3CDPIK3CG | |
| SCHEMBL1695420 | 0.84 | PIK3R2 (0.41) | PIK3R2PIK3CDPIK3CG | |
| SCHEMBL14815987 | 0.84 | PIK3R2 (0.47) | PIK3R2PIK3CDPIK3CG | |
| SCHEMBL1695012 | 0.84 | PIK3R2 (0.47) | PIK3R2PIK3CDPIK3CG | |
| SCHEMBL1695343 | 0.83 | PIK3R2 (0.41) | PIK3R2PIK3CDPIK3CG | |
| SCHEMBL1695024 | 0.81 | CNR2 (0.40) | PTGES |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2588467-A1 | HETEROCYCLIC COMPOUNDS AND THEIR USE AS INHIBITORS OF PI3K ACTIVITY | Amgen Inc. (US) | 2013-05-08 | — | — | EP | disclosed |
| WO-2012003274-A1 | HETEROCYCLIC COMPOUNDS AND THEIR USE AS INHIBITORS OF PI3K ACTIVITY | AMGEN INC. (US) | 2012-01-05 | — | — | WO | disclosed |