Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3R2 | O00459 | 14/20 | 0.41 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.38 |
| ▸ | PIK3CD | O00329 | 7/20 | 0.38 |
| ▸ | PIK3CG | P48736 | 5/20 | 0.38 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.37 |
| ▸ | CDK2 | P24941 | 2/20 | 0.37 |
| ▸ | CCNA1 | P78396 | 2/20 | 0.37 |
| ▸ | EGFR | P00533 | 1/20 | 0.36 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.36 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.36 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.35 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.35 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.35 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1695135 | 0.92 | PIK3R2 (0.43) | PIK3R2PIK3CDPIK3CGPIK3CAPIK3CB | |
| SCHEMBL1695242 | 0.90 | PIK3R2 (0.39) | PIK3R2PIK3CDPIK3CGPIK3CAPIK3CB | |
| SCHEMBL1694949 | 0.89 | PIK3R2 (0.39) | PIK3R2PIK3CDPIK3CGEGFRPIK3CA | |
| SCHEMBL1695309 | 0.89 | MAPK8 (0.43) | PIK3R2PIK3CDPIK3CGEGFR | |
| SCHEMBL1694834 | 0.89 | PIK3R2 (0.40) | PIK3R2PIK3CDPIK3CGPIK3CAPIK3CB | |
| SCHEMBL1694990 | 0.89 | PTGES (0.38) | PIK3R2MAP4K4PIK3CDPIK3CG | |
| SCHEMBL1695420 | 0.87 | PIK3R2 (0.41) | PIK3R2PIK3CDPIK3CGPIK3CAPIK3CB | |
| SCHEMBL1695362 | 0.87 | PIK3R2 (0.41) | PIK3R2MAP4K4PIK3CDPIK3CG | |
| SCHEMBL1694771 | 0.87 | HPGD (0.44) | PIK3CD | |
| SCHEMBL1695024 | 0.85 | CNR2 (0.40) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2588467-A1 | HETEROCYCLIC COMPOUNDS AND THEIR USE AS INHIBITORS OF PI3K ACTIVITY | Amgen Inc. (US) | 2013-05-08 | — | — | EP | disclosed |
| WO-2012003274-A1 | HETEROCYCLIC COMPOUNDS AND THEIR USE AS INHIBITORS OF PI3K ACTIVITY | AMGEN INC. (US) | 2012-01-05 | — | — | WO | disclosed |