Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 5/20 | 0.44 |
| ▸ | SGK1 | O00141 | 1/20 | 0.41 |
| ▸ | KDM5A | P29375 | 1/20 | 0.40 |
| ▸ | BRD4 | O60885 | 1/20 | 0.40 |
| ▸ | CCNE2 | O96020 | 3/20 | 0.40 |
| ▸ | CCNE1 | P24864 | 3/20 | 0.40 |
| ▸ | CDK2 | P24941 | 3/20 | 0.40 |
| ▸ | CCNB2 | O95067 | 2/20 | 0.40 |
| ▸ | CDK1 | P06493 | 2/20 | 0.40 |
| ▸ | CCNB1 | P14635 | 2/20 | 0.40 |
| ▸ | CCNB3 | Q8WWL7 | 2/20 | 0.40 |
| ▸ | BRAF | P15056 | 1/20 | 0.40 |
| ▸ | EIF2AK3 | Q9NZJ5 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30989267 | 0.80 | TSHR (0.50) | BRD4CCNE2CCNE1CDK2ALDH1A1 | |
| SCHEMBL15532940 | 0.80 | TSHR (0.50) | BRD4CCNE2CCNE1CDK2ALDH1A1 | |
| SCHEMBL1694708 | 0.78 | KDM4E (0.44) | ROCK2KDM5ABRD4CCNE2CCNE1 | |
| SCHEMBL29705507 | 0.78 | KDM4E (0.44) | ROCK2KDM5ABRD4CCNE2CCNE1 | |
| SCHEMBL2587386 | 0.77 | METTL3 (0.53) | — | |
| SCHEMBL29499046 | 0.76 | RET (0.46) | BRD4CCNE2CCNE1CDK2SMN1; SMN2 | |
| SCHEMBL1694892 | 0.76 | RET (0.46) | BRD4CCNE2CCNE1CDK2SMN1; SMN2 | |
| SCHEMBL30424537 | 0.75 | NUDT1 (0.64) | ALDH1A1MAPTJAK2JAK3 | |
| SCHEMBL14353567 | 0.75 | NUDT1 (0.64) | ALDH1A1MAPTJAK2JAK3 | |
| SCHEMBL31178646 | 0.74 | BRD4 (0.44) | ROCK2BRD4CCNE2CCNE1CDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2566479-A1 | AZAINDAZOLES | GlaxoSmithKline LLC (US) | 2013-03-13 | — | — | EP | disclosed |
| WO-2012005805-A1 | AZAINDAZOLES | GLAXOSMITHKLINE LLC (US) | 2012-01-12 | — | — | WO | disclosed |