Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.43 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | MTNR1A | P48039 | 2/20 | 0.42 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.42 |
| ▸ | HMGCR | P04035 | 1/20 | 0.42 |
| ▸ | ESR1 | P03372 | 1/20 | 0.41 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.41 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.41 |
| ▸ | PDE4A | P27815 | 1/20 | 0.41 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.41 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.41 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13802275 | 0.88 | ADRA1A (0.48) | ADRA1ATAAR1POLBMTNR1AMTNR1B | |
| SCHEMBL2061056 | 0.86 | KDM4E (0.50) | KDM4EALDH1A1ADRA1ATAAR1POLB | |
| SCHEMBL13221006 | 0.85 | HSD17B10 (0.47) | KDM4EALDH1A1ADRA1ATAAR1POLB | |
| SCHEMBL16962588 | 0.84 | NQO1 (0.45) | KDM4EALDH1A1MTNR1AMTNR1BESR2 | |
| SCHEMBL15935626 | 0.81 | POLB (0.49) | KDM4EALDH1A1ADRA1ATAAR1POLB | |
| SCHEMBL24079178 | 0.81 | ADRA1A (0.46) | ADRA1ATAAR1POLBMTNR1AMTNR1B | |
| SCHEMBL8275708 | 0.81 | ADRA1A (0.46) | ADRA1ATAAR1POLBMTNR1AMTNR1B | |
| SCHEMBL16884629 | 0.81 | DAO (0.43) | KDM4EALDH1A1ADRA1ATAAR1POLB | |
| SCHEMBL26046343 | 0.80 | POLB (0.69) | KDM4EALDH1A1POLBMTNR1AMTNR1B | |
| SCHEMBL26046405 | 0.80 | LMNA (0.56) | KDM4EALDH1A1POLBMTNR1AMTNR1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11746364-B2 | Enzymatic synthesis of kavalactones and flavokavains | WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH (US) | 2023-09-05 | — | — | US | disclosed |
| US-11739354-B2 | Enzymatic synthesis of kavalactones and flavokavains | WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH (US) | 2023-08-29 | — | — | US | disclosed |
| EP-2900645-A1 | 3-PHENYLISOXAZOLIN DERIVATIVES WITH HERBICIDAL ACTION | Bayer CropScience AG (DE) | 2015-08-05 | — | — | EP | disclosed |