SCHEMBL16952988

SCHEMBL16952988

C=C[C](C)c1cc(F)ccc1OCC

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MRGPRX1 Q96LB2 7/20 0.41
TSPO P30536 1/20 0.38
L3MBTL1 Q9Y468 2/20 0.37
CYP1A2 P05177 1/20 0.37
CYP2D6 P10635 1/20 0.37
CYP2C19 P33261 1/20 0.37
TDP1 Q9NUW8 1/20 0.37
CYP3A4 P08684 1/20 0.37
TSHR P16473 1/20 0.37
ALDH1A1 P00352 4/20 0.36
SMN1; SMN2 Q16637 2/20 0.36
MEN1 O00255 1/20 0.36
KMT2A Q03164 1/20 0.36
HTT P42858 1/20 0.36
HCRTR1 O43613 1/20 0.36
KDM4E B2RXH2 1/20 0.36
CREBBP Q92793 1/20 0.36
MAPT P10636 1/20 0.35
NPSR1 Q6W5P4 1/20 0.35
SCN8A Q9UQD0 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16950471 0.83 MAPT (0.43) MRGPRX1L3MBTL1TDP1CYP3A4TSHR
SCHEMBL16951749 0.82 NFE2L2 (0.41) ALDH1A1SMN1; SMN2MEN1KMT2AHTT
SCHEMBL16962098 0.82 MRGPRX1 (0.46) MRGPRX1TSPOL3MBTL1CYP1A2CYP2D6
SCHEMBL16951019 0.81 TSHR (0.50) CYP1A2CYP2D6TSHRMEN1KMT2A
SCHEMBL16954196 0.81 HPGD (0.50) L3MBTL1TSHRALDH1A1SMN1; SMN2KMT2A
SCHEMBL16953862 0.81 CYP2C19 (0.52) L3MBTL1CYP1A2CYP2C19CYP3A4ALDH1A1
SCHEMBL16956229 0.80 MTNR1A (0.47) CYP3A4TSHRSMN1; SMN2MEN1KMT2A
SCHEMBL3165420 0.79 CYP3A4 (0.61) MRGPRX1TSPOL3MBTL1CYP3A4TSHR
SCHEMBL16960638 0.79 MRGPRX1 (0.47) MRGPRX1TSPOL3MBTL1CYP1A2CYP2D6
SCHEMBL30628345 0.79 CYP3A4 (0.61) MRGPRX1TSPOL3MBTL1CYP3A4TSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2900645-A1 3-PHENYLISOXAZOLIN DERIVATIVES WITH HERBICIDAL ACTION Bayer CropScience AG (DE) 2015-08-05 EP disclosed