Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK8 | P45983 | 4/20 | 0.43 |
| ▸ | MAPK9 | P45984 | 4/20 | 0.43 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.43 |
| ▸ | PIK3R2 | O00459 | 4/20 | 0.40 |
| ▸ | PIK3CD | O00329 | 3/20 | 0.40 |
| ▸ | EGFR | P00533 | 1/20 | 0.40 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.40 |
| ▸ | RPS27 | P42677 | 1/20 | 0.40 |
| ▸ | AURKA | O14965 | 4/20 | 0.40 |
| ▸ | RPS6KB1 | P23443 | 3/20 | 0.40 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.40 |
| ▸ | GALR3 | O60755 | 1/20 | 0.38 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.37 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.36 |
| ▸ | MMP13 | P45452 | 1/20 | 0.36 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1695135 | 0.90 | PIK3R2 (0.43) | PIK3R2PIK3CDPIK3CG | |
| SCHEMBL1694771 | 0.90 | HPGD (0.44) | PIK3CDAURKARPS6KB1 | |
| SCHEMBL1695343 | 0.89 | PIK3R2 (0.41) | PIK3R2PIK3CDEGFRPIK3CG | |
| SCHEMBL1695242 | 0.89 | PIK3R2 (0.39) | PIK3R2PIK3CDPIK3CG | |
| SCHEMBL1694949 | 0.89 | PIK3R2 (0.39) | PIK3R2PIK3CDEGFRERBB2PIK3CG | |
| SCHEMBL1694990 | 0.86 | PTGES (0.38) | PIK3R2PIK3CDPIK3CG | |
| SCHEMBL1695420 | 0.85 | PIK3R2 (0.41) | PIK3R2PIK3CDPIK3CG | |
| SCHEMBL1695362 | 0.85 | PIK3R2 (0.41) | PIK3R2PIK3CDPIK3CG | |
| SCHEMBL1694834 | 0.85 | PIK3R2 (0.40) | MAPK8MAPK9MAPK10PIK3R2PIK3CD | |
| SCHEMBL1695407 | 0.84 | PIK3R2 (0.37) | PIK3R2PIK3CDPIK3CG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2588467-A1 | HETEROCYCLIC COMPOUNDS AND THEIR USE AS INHIBITORS OF PI3K ACTIVITY | Amgen Inc. (US) | 2013-05-08 | — | — | EP | disclosed |
| WO-2012003274-A1 | HETEROCYCLIC COMPOUNDS AND THEIR USE AS INHIBITORS OF PI3K ACTIVITY | AMGEN INC. (US) | 2012-01-05 | — | — | WO | disclosed |