Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 4/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | F2 | P00734 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.40 |
| ▸ | SRC | P12931 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 4/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | CASP3 | P42574 | 1/20 | 0.39 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.39 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.39 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.39 |
| ▸ | CTSD | P07339 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1536367 | 0.81 | TSHR (0.59) | TSHRMAPTKMT2AALDH1A1POLB | |
| SCHEMBL16403663 | 0.81 | TSHR (0.59) | TSHRMAPTKMT2AALDH1A1POLB | |
| SCHEMBL1536368 | 0.81 | TSHR (0.59) | TSHRMAPTKMT2AALDH1A1POLB | |
| SCHEMBL3189100 | 0.81 | TSHR (0.59) | TSHRMAPTKMT2AALDH1A1POLB | |
| SCHEMBL1137903 | 0.79 | TSHR (0.57) | TSHRMAPTKMT2AALDH1A1POLB | |
| SCHEMBL14852715 | 0.79 | TSHR (0.57) | TSHRMAPTKMT2AALDH1A1F2 | |
| SCHEMBL7073576 | 0.78 | TSHR (0.55) | TSHRMAPTKMT2AALDH1A1POLB | |
| SCHEMBL11479646 | 0.78 | DEGS1 (0.58) | TSHRMAPTKMT2AALDH1A1POLB | |
| SCHEMBL15880803 | 0.78 | TSHR (0.55) | TSHRMAPTKMT2AALDH1A1POLB | |
| SCHEMBL11476507 | 0.77 | HDAC1 (0.46) | TSHRMAPTKMT2AALDH1A1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011138657-A1 | ARYL SUBSTITUTED OLEFINIC COMPOUNDS AS PDE10A INHIBITORS | GLENMARK PHARMACEUTICALS S.A. (CH) | 2011-11-10 | — | — | WO | disclosed |