Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NTRK1 | P04629 | 1/20 | 0.38 |
| ▸ | KIF5C | O60282 | 1/20 | 0.38 |
| ▸ | KIF11 | P52732 | 1/20 | 0.38 |
| ▸ | KIF5A | Q12840 | 1/20 | 0.38 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.37 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.37 |
| ▸ | MAP3K14 | Q99558 | 1/20 | 0.37 |
| ▸ | MAPK14 | Q16539 | 5/20 | 0.36 |
| ▸ | ALPL | P05186 | 2/20 | 0.36 |
| ▸ | KCNMA1 | Q12791 | 1/20 | 0.36 |
| ▸ | GRIN1 | Q05586 | 4/20 | 0.36 |
| ▸ | GRIN2B | Q13224 | 4/20 | 0.36 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.36 |
| ▸ | POLQ | O75417 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13735546 | 0.78 | IDO1 (0.33) | — | |
| SCHEMBL168619 | 0.77 | GRM2 (0.41) | ALPL | |
| SCHEMBL29812342 | 0.73 | HAO2 (0.45) | NTRK1KIF5CKIF11KIF5APDE3B | |
| SCHEMBL29812436 | 0.72 | PTPN11 (0.38) | KIF5CKIF11KIF5AMAP3K14MAPK14 | |
| SCHEMBL29822281 | 0.71 | GRM2 (0.39) | ALPL | |
| SCHEMBL169065 | 0.70 | — | — | |
| SCHEMBL14398387 | 0.70 | KEAP1 (0.37) | ALPL | |
| SCHEMBL29812288 | 0.70 | MAPK14 (0.39) | KIF5CKIF11KIF5AMAP3K14MAPK14 | |
| SCHEMBL14039912 | 0.70 | PDE3B (0.44) | PDE3BPDE3AGPBAR1 | |
| SCHEMBL29812433 | 0.69 | LRRK2 (0.38) | PDE3BPDE3AMAP3K14MAPK14POLQ |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2609091-A1 | PHARMACEUTICALLY ACTIVE COMPOUNDS AS AXL INHIBITORS | Lead Discovery Center GmbH (DE) | 2013-07-03 | — | — | EP | disclosed |
| WO-2012028332-A1 | PHARMACEUTICALLY ACTIVE COMPOUNDS AS AXL INHIBITORS | LEAD DISCOVERY CENTER GMBH (DE) | 2012-03-08 | — | — | WO | disclosed |