SCHEMBL16958554

SCHEMBL16958554

COc1ccc(F)c([CH]O)c1

nearest known ligand 0.49

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
NFE2L2 Q16236 5/20 0.49
ERN1 O75460 2/20 0.47
CYP1A1 P04798 3/20 0.46
CYP1A2 P05177 3/20 0.46
CYP1B1 Q16678 3/20 0.46
RELA Q04206 1/20 0.43
TRIM24 O15164 1/20 0.43
TYR P14679 1/20 0.43
TRIM33 Q9UPN9 1/20 0.43
JUN P05412 1/20 0.42
NFKB1 P19838 1/20 0.42
MAOB P27338 1/20 0.41
AMY1A P0DUB6 1/20 0.41
ALDH1A1 P00352 1/20 0.40
CPS1 P31327 1/20 0.40
CHRM2 P08172 1/20 0.40
CHRM1 P11229 1/20 0.40
CHRM3 P20309 1/20 0.40
ABCG2 Q9UNQ0 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5442396 0.84 NFE2L2 (0.49) NFE2L2ERN1CYP1A1CYP1A2CYP1B1
SCHEMBL28337714 0.82 NFE2L2 (0.50) NFE2L2ERN1CYP1A1CYP1A2CYP1B1
SCHEMBL20256342 0.80 NFE2L2 (0.49) NFE2L2ERN1CYP1A1CYP1A2CYP1B1
SCHEMBL387186 0.80 ERN1 (0.61) NFE2L2ERN1CYP1A1CYP1A2CYP1B1
SCHEMBL18490047 0.79 KMT2A (0.54) NFE2L2ERN1CYP1A1CYP1A2CYP1B1
SCHEMBL5764749 0.79 KMT2A (0.54) NFE2L2ERN1CYP1A1CYP1A2CYP1B1
SCHEMBL16950675 0.79 NQO1 (0.45) ALDH1A1
SCHEMBL16958556 0.78 ERN1 (0.48) NFE2L2ERN1CYP1A1CYP1A2CYP1B1
SCHEMBL6631188 0.78 CYP1A1 (0.61) NFE2L2ERN1CYP1A1CYP1A2CYP1B1
SCHEMBL7483621 0.77 NFE2L2 (0.54) NFE2L2ERN1CYP1A1CYP1A2CYP1B1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2900645-A1 3-PHENYLISOXAZOLIN DERIVATIVES WITH HERBICIDAL ACTION Bayer CropScience AG (DE) 2015-08-05 EP disclosed