Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NTMT1 | Q9BV86 | 2/20 | 0.45 |
| ▸ | CHRM3 | P20309 | 8/20 | 0.44 |
| ▸ | CHRM2 | P08172 | 6/20 | 0.44 |
| ▸ | CHRM1 | P11229 | 6/20 | 0.44 |
| ▸ | CHRNA7 | P36544 | 3/20 | 0.43 |
| ▸ | BCHE | P06276 | 1/20 | 0.43 |
| ▸ | ACHE | P22303 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16476711 | 1.00 | NTMT1 (0.45) | NTMT1CHRM3CHRM2CHRM1CHRNA7 | |
| SCHEMBL1696312 | 1.00 | NTMT1 (0.45) | NTMT1CHRM3CHRM2CHRM1CHRNA7 | |
| SCHEMBL1696095 | 0.91 | CHRNA7 (0.51) | CHRM3CHRM2CHRM1CHRNA7BCHE | |
| SCHEMBL12071893 | 0.91 | CHRNA7 (0.51) | CHRM3CHRM2CHRM1CHRNA7BCHE | |
| SCHEMBL1696141 | 0.91 | CHRNA7 (0.51) | CHRM3CHRM2CHRM1CHRNA7BCHE | |
| SCHEMBL1696173 | 0.91 | CHRNA7 (0.51) | CHRM3CHRM2CHRM1CHRNA7BCHE | |
| SCHEMBL1696097 | 0.91 | CHRNA7 (0.51) | CHRM3CHRM2CHRM1CHRNA7BCHE | |
| SCHEMBL1696093 | 0.91 | CHRNA7 (0.51) | CHRM3CHRM2CHRM1CHRNA7BCHE | |
| SCHEMBL16460944 | 0.88 | CYP2D6 (0.45) | CHRM3CHRM2CHRM1CHRNA7BCHE | |
| SCHEMBL16460946 | 0.88 | CYP2D6 (0.45) | CHRM3CHRM2CHRM1CHRNA7BCHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2585457-B1 | Alkaloid aminoester derivatives and medicinal composition thereof | CHIESI FARMA SPA (IT) | 2015-07-22 | — | — | EP | disclosed |
| US-8629160-B2 | Alkaloid aminoester derivatives and medicinal composition thereof | CHIESI FARMACEUTICI S.P.A. (IT) | 2014-01-14 | — | — | US | disclosed |
| EP-2585457-A1 | ALKALOID AMINOESTER DERIVATIVES AND MEDICINAL COMPOSITION THEREOF | Chiesi Farmaceutici S.p.A. (IT) | 2013-05-01 | — | — | EP | disclosed |
| WO-2011160918-A1 | ALKALOID AMINOESTER DERIVATIVES AND MEDICINAL COMPOSITION THEREOF | CHIESI FARMACEUTICI S.P.A. (IT) | 2011-12-29 | — | — | WO | disclosed |
| US-20110311461-A1 | ALKALOID AMINOESTER DERIVATIVES AND MEDICINAL COMPOSITION THEREOF | CHIESI FARMACEUTICI S.P.A. (IT) | 2011-12-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110311461-A1 | ALKALOID AMINOESTER DERIVATIVES AND MEDICINAL COMPOSITION THEREOF | CHRM3, CHRM2, CHRM5 | NTMT1 445/4885CHRM3 1/4885CHRM2 2/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.