Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 1/20 | 0.43 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.36 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.36 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.36 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.36 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.36 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.35 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.34 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.34 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.34 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.34 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23476568 | 0.89 | HTR1A (0.38) | HTR1APSEN1PSEN2APH1BNCSTN | |
| SCHEMBL19091274 | 0.88 | CHRM5 (0.43) | HTR1ACYP1B1CHRM2CHRM4CHRM5 | |
| SCHEMBL1920814 | 0.85 | HTR1A (0.37) | HTR1APSEN1PSEN2APH1BNCSTN | |
| SCHEMBL2519541 | 0.85 | HTR1A (0.37) | HTR1APSEN1PSEN2APH1BNCSTN | |
| SCHEMBL535579 | 0.84 | PLG (0.47) | HTR1APOLBSMN1; SMN2MEN1ALDH1A1 | |
| SCHEMBL16552327 | 0.84 | PLG (0.47) | HTR1APOLBSMN1; SMN2MEN1ALDH1A1 | |
| SCHEMBL17532449 | 0.83 | HTR1A (0.37) | HTR1APSEN1PSEN2APH1BNCSTN | |
| SCHEMBL17145362 | 0.82 | SMN1; SMN2 (0.38) | HTR1APOLBSMN1; SMN2MEN1ALDH1A1 | |
| SCHEMBL23476597 | 0.82 | SMN1; SMN2 (0.38) | HTR1APOLBSMN1; SMN2MEN1ALDH1A1 | |
| SCHEMBL10082604 | 0.82 | HTT (0.37) | HTR1APOLBSMN1; SMN2RAB9AADRB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2900242-A1 | SUBSTITUTED CYCLOPROPYL COMPOUNDS | Merck Sharp & Dohme Corp. (US) | 2015-08-05 | — | — | EP | disclosed |