SCHEMBL1696703

SCHEMBL1696703

NC([C]=O)Cc1ccco1

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALOX5 P09917 1/20 0.43
SLC1A3 P43003 1/20 0.41
SLC1A2 P43004 1/20 0.41
SLC1A1 P43005 1/20 0.41
MAOB P27338 1/20 0.39
ALDH1A1 P00352 5/20 0.37
GAA P10253 2/20 0.36
CYP3A4 P08684 1/20 0.36
ALOX15 P16050 1/20 0.36
MAPT P10636 2/20 0.36
KDM4E B2RXH2 1/20 0.36
HSD17B10 Q99714 1/20 0.36
HPGD P15428 1/20 0.36
NPC1 O15118 1/20 0.35
RAB9A P51151 1/20 0.35
TSHR P16473 1/20 0.35
KMT2A Q03164 1/20 0.35
USP2 O75604 1/20 0.35
L3MBTL1 Q9Y468 1/20 0.35
CHRM2 P08172 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1696704 1.00 ALOX5 (0.43) ALOX5SLC1A3SLC1A2SLC1A1MAOB
SCHEMBL29175498 0.77
SCHEMBL1915949 0.76 MAOB (0.38) ALOX5MAOBALDH1A1CYP3A4ALOX15
SCHEMBL2022682 0.74
SCHEMBL9755560 0.74
SCHEMBL14478276 0.74
SCHEMBL4657408 0.74
SCHEMBL13692285 0.74
SCHEMBL10664022 0.73 SLC1A3 (0.44) ALOX5SLC1A3SLC1A2SLC1A1MAOB
SCHEMBL1696705 0.73 SLC1A3 (0.44) ALOX5SLC1A3SLC1A2SLC1A1MAOB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 41 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2585482-B1 GLUCAGON ANALOGUES ZEALAND PHARMA AS (DK) 2019-03-27 EP claimed
US-20150376257-A1 GLUCAGON ANALOGUES ZEALAND PHARMA A/S (DK) 2015-12-31 US claimed
US-20130157929-A1 GLUCAGON ANALOGUES ZEALAND PHARMA A/S (DK) 2013-06-20 US claimed
EP-2585482-A1 GLUCAGON ANALOGUES Zealand Pharma A/S (DK) 2013-05-01 EP claimed
WO-2011160633-A1 GLUCAGON ANALOGUES ZEALAND PHARMA A/S (DK) 2011-12-29 WO claimed
US-7335516-B2 Methods to improve immunogenicity of antigens and specificity of antibodies SEREX, INC. (US) 2008-02-26 US claimed
US-20060194737-A1 Hepta-, octa-and nonapeptides having antiangiogenic activity HAVIV FORTUNA 2006-08-31 US claimed
US-7067490-B2 Hepta-, Octa-and nonapeptides having antiangiogenic activity ABBOTT LABORATORIES (US) 2006-06-27 US claimed
EP-1451210-A2 HEPTA-, OCTA- AND NONAPEPTIDES HAVING ANTIANGIOGENIC ACTIVITY Abbott Laboratories (US) 2004-09-01 EP claimed
EP-1421107-A1 PEPTIDES HAVING ANTIANGIOGENIC ACTIVITY Abbott Laboratories (US) 2004-05-26 EP claimed
US-20030125259-A1 Octa- and nonapeptides having antiangiogenic activity ABBOTT LABORATORIES 2003-07-03 US claimed
US-20030109455-A1 HEPTA-, OCTA-and nonapeptides having antiangiogenic activity ABBVIE INC. 2003-06-12 US claimed
US-20030096758-A1 HEPTA-, OCTA- and nonapeptides having antiangiogenic activity ABBOTT LABORATORIES 2003-05-22 US claimed
WO-2003037268-A2 HEPTA-, OCTA- AND NONAPEPTIDES HAVING ANTIANGIOGENIC ACTIVITY ABBOTT LABORATORIES (US) 2003-05-08 WO claimed
US-20030050246-A1 Peptides having antiangiogenic activity ABBOTT LABORATORIES 2003-03-13 US claimed
US-20030045477-A1 Peptides having antiangiogenic activity ABBOTT LABORATORIES 2003-03-06 US claimed
WO-2003011896-A1 PEPTIDES HAVING ANTIANGIOGENIC ACTIVITY ABBOTT LABORATORIES (US) 2003-02-13 WO claimed
EP-2585482-B1 GLUCAGON ANALOGUES ZEALAND PHARMA AS (DK) 2019-03-27 EP disclosed
US-20030045477-A1 Peptides having antiangiogenic activity ABBOTT LABORATORIES 2003-03-06 US disclosed
WO-2003011896-A1 PEPTIDES HAVING ANTIANGIOGENIC ACTIVITY ABBOTT LABORATORIES (US) 2003-02-13 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20150376257-A1 GLUCAGON ANALOGUES GLP1R, GCGR, GIPR ALOX5 4000/4885SLC1A3 2769/4885SLC1A2 4014/4885
US-20130157929-A1 GLUCAGON ANALOGUES GLP1R, GCGR, GIPR ALOX5 4000/4885SLC1A3 2769/4885SLC1A2 4014/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.