Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT2 | Q8IXJ6 | 8/20 | 0.41 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.41 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.41 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.41 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.41 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.41 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.41 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.41 |
| ▸ | CDC25B | P30305 | 1/20 | 0.40 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.39 |
| ▸ | CTSV | O60911 | 1/20 | 0.39 |
| ▸ | CTSL | P07711 | 1/20 | 0.39 |
| ▸ | PPARG | P37231 | 1/20 | 0.39 |
| ▸ | PPARA | Q07869 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.38 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.38 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL370943 | 0.87 | PPARA (0.49) | SIRT2PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL15416998 | 0.86 | KMT2A (0.45) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL371036 | 0.83 | PSEN1 (0.44) | SIRT2PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL1697010 | 0.81 | PPARA (0.56) | SIRT2PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL12503324 | 0.80 | PPARA (0.60) | SIRT2PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL344104 | 0.80 | THRB (0.44) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL344686 | 0.80 | PPARA (0.47) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL343323 | 0.79 | PPARA (0.48) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL344807 | 0.79 | PPARA (0.48) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL15417050 | 0.78 | KDR (0.51) | ROCK2ROCK1ALDH1A1CYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012003145-A2 | THERAPEUTIC AGENTS FOR OCULAR HYPERTENSION | ALLERGAN, INC. (US) | 2012-01-05 | — | — | WO | disclosed |