Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.57 |
| ▸ | LMNA | P02545 | 1/20 | 0.57 |
| ▸ | ALB | P02768 | 1/20 | 0.57 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.57 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | POLA1 | P09884 | 1/20 | 0.44 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.43 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.43 |
| ▸ | ABL1 | P00519 | 1/20 | 0.39 |
| ▸ | RIN1 | Q13671 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3484940 | 1.00 | KDM4E (0.62) | KDM4EALDH1A1LMNAALBMAPK1 | |
| SCHEMBL21392956 | 1.00 | KDM4E (0.62) | KDM4EALDH1A1LMNAALBMAPK1 | |
| SCHEMBL22990581 | 1.00 | KDM4E (0.62) | KDM4EALDH1A1LMNAALBMAPK1 | |
| SCHEMBL21376540 | 0.93 | ALDH1A1 (0.55) | KDM4EALDH1A1LMNAALBMAPK1 | |
| SCHEMBL18963575 | 0.93 | ALDH1A1 (0.55) | KDM4EALDH1A1LMNAALBMAPK1 | |
| SCHEMBL21393208 | 0.93 | KDM4E (0.58) | KDM4EALDH1A1LMNAALBMAPK1 | |
| SCHEMBL21393042 | 0.92 | KDM4E (0.57) | KDM4EALDH1A1LMNAALBMAPK1 | |
| SCHEMBL26196576 | 0.91 | KDM4E (0.57) | KDM4EALDH1A1LMNAALBMAPK1 | |
| SCHEMBL18963691 | 0.90 | KDM4E (0.58) | KDM4EALDH1A1LMNAALBMAPK1 | |
| SCHEMBL31093232 | 0.88 | KDM4E (0.67) | KDM4EALDH1A1LMNAALBMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3344644-B1 | CYCLIC DI-NUCLEOTIDE COMPOUNDS AS STING AGONISTS | MERCK SHARP & DOHME LLC (US) | 2024-06-26 | — | — | EP | disclosed |
| WO-2023220737-A2 | OLIGONUCLEOTIDES HAVING A SYNTHETIC BACKBONE AND SYNTHESIS THEREOF | ADARX PHARMACEUTICALS, INC. (US) | 2023-11-16 | — | — | WO | disclosed |
| EP-4242212-A2 | STING MODULATOR COMPOUNDS WITH SULFAMATE LINKAGES, AND METHODS OF MAKING AND USING | Takeda Pharmaceutical Company Limited (JP) | 2023-09-13 | — | — | EP | disclosed |
| EP-3621624-B1 | CYCLIC DI-NUCLEOTIDE COMPOUNDS AS STING AGONISTS | MERCK SHARP & DOHME LLC (US) | 2023-08-30 | — | — | EP | disclosed |
| WO-2021030763-A1 | MODIFIED OLIGOMERIC COMPOUNDS AND USES THEREOF | IONIS PHARMACEUTICALS, INC. (US) | 2021-02-18 | — | — | WO | disclosed |
| US-20170305954-A1 | SYNTHESIS OF 2', 3'-DIDEOXYNUCLEOSIDES FOR AUTOMATED DNA SYNTHESIS AND PYROPHOSPHOROLYSIS ACTIVATED POLYMERIZATION | Life Technologies Corporation (US) | 2017-10-26 | — | — | US | disclosed |
| US-9732112-B2 | Synthesis of 2′,3′-dideoxynucleosides for automated DNA synthesis and pyrophosphorolysis activated polymerization | Life Technologies Corporation (US) | 2017-08-15 | — | — | US | disclosed |
| US-20160108079-A1 | Synthesis Of 2',3'-Dideoxynucleosides For Automated DNA Synthesis And Pyrophosphorolysis Activated Polymerization | Life Technologies Corporation | 2016-04-21 | — | — | US | disclosed |
| US-9228227-B2 | Synthesis of 2′, 3′-dideoxynucleosides for automated DNA synthesis and pyrophosphorolysis activated polymerization | Life Technologies Corporation (US) | 2016-01-05 | — | — | US | disclosed |
| EP-2576577-B1 | SYNTHESIS OF 2', 3'-DIDEOXYNUCLEOSIDES FOR AUTOMATED DNA SYNTHESIS AND PYROPHOSPHOROLYSIS ACTIVATED POLYMERIZATION | LIFE TECHNOLOGIES CORP (US) | 2015-03-18 | — | — | EP | disclosed |
| US-20150045547-A1 | Synthesis Of 2' , 3' -Dideoxynucleosides For Automated DNA Synthesis And Pyrophosphorolysis Activated Polymerization | Life Technologies Corporation (US) | 2015-02-12 | — | — | US | disclosed |
| US-8658776-B2 | Synthesis of 2′,3′-dideoxynucleosides for automated DNA synthesis and pyrophosphorolysis activated polymerization | Life Technologies Corporation (US) | 2014-02-25 | — | — | US | disclosed |
| EP-2576577-A2 | SYNTHESIS OF 2', 3'-DIDEOXYNUCLEOSIDES FOR AUTOMATED DNA SYNTHESIS AND PYROPHOSPHOROLYSIS ACTIVATED POLYMERIZATION | Life Technologies Corporation (US) | 2013-04-10 | — | — | EP | disclosed |
| WO-2011150277-A2 | SYNTHESIS OF 2', 3'-DIDEOXYNUCLEOSIDES FOR AUTOMATED DNA SYNTHESIS AND PYROPHOSPHOROLYSIS ACTIVATED POLYMERIZATION | Life Technologies Corporation (US) | 2011-12-01 | — | — | WO | disclosed |
| US-20110294122-A1 | Synthesis of 2', 3'-Dideoxynucleosides for Automated DNA Synthesis and Pyrophosphorolysis Activated Polymerization | Life Technologies Corporation (US) | 2011-12-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170305954-A1 | SYNTHESIS OF 2', 3'-DIDEOXYNUCLEOSIDES FOR AUTOMATED DNA SYNTHESIS AND PYROPHOSPHOROLYSIS ACTIVATED POLYMERIZATION | DCTD, MTAP, RNGTT | KDM4E 2128/4885ALDH1A1 3479/4885LMNA 1311/4885 |
| US-20160108079-A1 | Synthesis Of 2',3'-Dideoxynucleosides For Automated DNA Synthesis And Pyrophosphorolysis Activated Polymerization | DCTD, MTAP, RNGTT | KDM4E 2128/4885ALDH1A1 3479/4885LMNA 1311/4885 |
| US-20110294122-A1 | Synthesis of 2', 3'-Dideoxynucleosides for Automated DNA Synthesis and Pyrophosphorolysis Activated Polymerization | DCTD, MTAP, RNGTT | KDM4E 2128/4885ALDH1A1 3479/4885LMNA 1311/4885 |
| US-20150045547-A1 | Synthesis Of 2' , 3' -Dideoxynucleosides For Automated DNA Synthesis And Pyrophosphorolysis Activated Polymerization | DCTD, MTAP, RNGTT | KDM4E 2128/4885ALDH1A1 3479/4885LMNA 1311/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.