Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKAA2 | P54646 | 5/20 | 0.46 |
| ▸ | PRKAB2 | O43741 | 4/20 | 0.46 |
| ▸ | PRKAG1 | P54619 | 4/20 | 0.46 |
| ▸ | PRKAA1 | Q13131 | 4/20 | 0.46 |
| ▸ | PRKAG3 | Q9UGI9 | 4/20 | 0.46 |
| ▸ | PRKAG2 | Q9UGJ0 | 4/20 | 0.46 |
| ▸ | PRKAB1 | Q9Y478 | 4/20 | 0.46 |
| ▸ | SMYD3 | Q9H7B4 | 4/20 | 0.42 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.41 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.41 |
| ▸ | CNR1 | P21554 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16973816 | 0.86 | SIRT6 (0.42) | PRKAA2PRKAB2PRKAG1PRKAA1PRKAG3 | |
| SCHEMBL14315886 | 0.85 | SIRT6 (0.50) | SMYD3SIRT6CNR1 | |
| SCHEMBL16984667 | 0.82 | USP30 (0.57) | USP30CNR1 | |
| SCHEMBL22565328 | 0.81 | CNR1 (0.56) | CNR1 | |
| SCHEMBL16973722 | 0.81 | ACKR3 (0.51) | PRKAA2PRKAB2PRKAG1PRKAA1PRKAG3 | |
| SCHEMBL16973635 | 0.81 | PRKAA2 (0.44) | PRKAA2PRKAB2PRKAG1PRKAA1PRKAG3 | |
| SCHEMBL16973688 | 0.80 | CD38 (0.42) | PRKAA2PRKAB2PRKAG1PRKAA1PRKAG3 | |
| SCHEMBL16973832 | 0.80 | PRKAA2 (0.48) | PRKAA2PRKAB2PRKAG1PRKAA1PRKAG3 | |
| SCHEMBL16973839 | 0.79 | SMYD3 (0.50) | SMYD3SIRT6CNR1 | |
| SCHEMBL16973629 | 0.79 | HPGDS (0.54) | PRKAA2PRKAB2PRKAG1PRKAA1PRKAG3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015113927-A1 | AMINO-SUBSTITUTED ISOTHIAZOLES | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2015-08-06 | — | — | WO | disclosed |