Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 2/20 | 0.34 |
| ▸ | BACE1 | P56817 | 1/20 | 0.34 |
| ▸ | HCAR1 | Q9BXC0 | 3/20 | 0.33 |
| ▸ | MTOR | P42345 | 1/20 | 0.33 |
| ▸ | BRD4 | O60885 | 1/20 | 0.33 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.33 |
| ▸ | GHSR | Q92847 | 1/20 | 0.33 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16975283 | 0.90 | MTOR (0.34) | ABL1MTORPIK3CD | |
| SCHEMBL16975227 | 0.88 | MTOR (0.36) | ABL1HCAR1MTORBRD4HCAR2 | |
| SCHEMBL16975323 | 0.88 | BRD4 (0.38) | HCAR1MTORBRD4 | |
| SCHEMBL16975328 | 0.88 | MTOR (0.37) | ABL1HCAR1MTORPIK3CD | |
| SCHEMBL16975299 | 0.88 | HCAR1 (0.35) | ABL1HCAR1HCAR2GHSR | |
| SCHEMBL16975300 | 0.87 | MTOR (0.37) | ABL1HCAR1MTORPIK3CD | |
| SCHEMBL16975329 | 0.87 | JAK2 (0.37) | ABL1MTORBRD4PIK3CD | |
| SCHEMBL16975327 | 0.86 | JAK2 (0.36) | ABL1MTORBRD4PIK3CD | |
| SCHEMBL16975261 | 0.80 | ABL1 (0.40) | ABL1PIK3CD | |
| SCHEMBL16975481 | 0.78 | ABL1 (0.40) | ABL1PIK3CD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3102203-A2 | ANTIBACTERIAL COMBINATIONS COMPRISING POLYMYXIN | SPERO GYRASE, INC. (US) | 2016-12-14 | — | — | EP | claimed |
| WO-2015114452-A2 | ANTIBACTERIAL COMPOUNDS | BIOTA EUROPE LTD (GB) | 2015-08-06 | — | — | WO | claimed |
| EP-3102203-A2 | ANTIBACTERIAL COMBINATIONS COMPRISING POLYMYXIN | SPERO GYRASE, INC. (US) | 2016-12-14 | — | — | EP | disclosed |
| WO-2015114452-A2 | ANTIBACTERIAL COMPOUNDS | BIOTA EUROPE LTD (GB) | 2015-08-06 | — | — | WO | disclosed |