Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 8/20 | 0.38 |
| ▸ | JAK1 | P23458 | 2/20 | 0.37 |
| ▸ | JAK3 | P52333 | 2/20 | 0.37 |
| ▸ | BRDT | Q58F21 | 2/20 | 0.37 |
| ▸ | MTOR | P42345 | 1/20 | 0.36 |
| ▸ | HCAR1 | Q9BXC0 | 2/20 | 0.36 |
| ▸ | JAK2 | O60674 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16975328 | 0.94 | MTOR (0.37) | MTORHCAR1 | |
| SCHEMBL16975300 | 0.93 | MTOR (0.37) | MTORHCAR1 | |
| SCHEMBL16975227 | 0.92 | MTOR (0.36) | BRD4JAK3BRDTMTORHCAR1 | |
| SCHEMBL16975329 | 0.92 | JAK2 (0.37) | BRD4MTORJAK2 | |
| SCHEMBL16975327 | 0.91 | JAK2 (0.36) | BRD4JAK1JAK3BRDTMTOR | |
| SCHEMBL16975299 | 0.90 | HCAR1 (0.35) | HCAR1 | |
| SCHEMBL16975283 | 0.89 | MTOR (0.34) | MTOR | |
| SCHEMBL16975267 | 0.88 | ABL1 (0.34) | BRD4MTORHCAR1 | |
| SCHEMBL16975261 | 0.84 | ABL1 (0.40) | — | |
| SCHEMBL16975481 | 0.83 | ABL1 (0.40) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3102203-A2 | ANTIBACTERIAL COMBINATIONS COMPRISING POLYMYXIN | SPERO GYRASE, INC. (US) | 2016-12-14 | — | — | EP | claimed |
| WO-2015114452-A2 | ANTIBACTERIAL COMPOUNDS | BIOTA EUROPE LTD (GB) | 2015-08-06 | — | — | WO | claimed |
| EP-3102203-A2 | ANTIBACTERIAL COMBINATIONS COMPRISING POLYMYXIN | SPERO GYRASE, INC. (US) | 2016-12-14 | — | — | EP | disclosed |
| WO-2015114452-A2 | ANTIBACTERIAL COMPOUNDS | BIOTA EUROPE LTD (GB) | 2015-08-06 | — | — | WO | disclosed |