Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 8/20 | 0.38 |
| ▸ | IRAK4 | Q9NWZ3 | 4/20 | 0.37 |
| ▸ | CNR1 | P21554 | 2/20 | 0.37 |
| ▸ | BRD4 | O60885 | 1/20 | 0.36 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.36 |
| ▸ | JAK3 | P52333 | 1/20 | 0.35 |
| ▸ | CDC7 | O00311 | 1/20 | 0.35 |
| ▸ | PIM1 | P11309 | 1/20 | 0.35 |
| ▸ | GSK3B | P49841 | 1/20 | 0.35 |
| ▸ | FER | P16591 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16977244 | 0.90 | SYK (0.41) | SYKEPHX2JAK3FER | |
| SCHEMBL13333460 | 0.81 | SYK (0.43) | SYKBRD4 | |
| SCHEMBL16977239 | 0.79 | SYK (0.46) | SYKIRAK4 | |
| SCHEMBL16977212 | 0.79 | PDE4A (0.42) | SYKIRAK4JAK3 | |
| SCHEMBL16977189 | 0.73 | CHRM3 (0.34) | — | |
| SCHEMBL16977188 | 0.69 | SYK (0.52) | SYK | |
| SCHEMBL16977215 | 0.69 | SYK (0.43) | SYK | |
| SCHEMBL16977225 | 0.64 | JAK2 (0.35) | JAK3 | |
| SCHEMBL4065551 | 0.63 | ALDH1A1 (0.51) | SYKCDC7PIM1GSK3BFER | |
| SCHEMBL7020150 | 0.63 | ALDH1A1 (0.51) | SYKCDC7PIM1GSK3BFER |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2358204-B1 | 4,5,7,8-tetrahydro-4-oxo-2H-imidazo[1,2-a]pyrrolo[3,4-e]pyrimidine compounds as PDE1 inhibitors. | INTRA CELLULAR THERAPIES INC (US) | 2015-08-05 | — | — | EP | disclosed |