Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 2/20 | 0.42 |
| ▸ | PDE5A | O76074 | 1/20 | 0.42 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.42 |
| ▸ | PDE11A | Q9HCR9 | 1/20 | 0.42 |
| ▸ | PDE7B | Q9NP56 | 1/20 | 0.42 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.42 |
| ▸ | SYK | P43405 | 9/20 | 0.40 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.38 |
| ▸ | JAK2 | O60674 | 1/20 | 0.36 |
| ▸ | JAK1 | P23458 | 1/20 | 0.36 |
| ▸ | TYK2 | P29597 | 1/20 | 0.36 |
| ▸ | JAK3 | P52333 | 1/20 | 0.36 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.36 |
| ▸ | IRAK4 | Q9NWZ3 | 4/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16977215 | 0.92 | SYK (0.43) | PDE4APDE5APDE3BPDE11APDE7B | |
| SCHEMBL13333460 | 0.83 | SYK (0.43) | SYKCHRM1 | |
| SCHEMBL16977239 | 0.81 | SYK (0.46) | PDE4APDE5APDE3BPDE11APDE7B | |
| SCHEMBL16977211 | 0.79 | SYK (0.38) | SYKJAK3IRAK4 | |
| SCHEMBL16977188 | 0.72 | SYK (0.52) | PDE4APDE5APDE3BPDE11APDE7B | |
| SCHEMBL16977244 | 0.69 | SYK (0.41) | SYKJAK3 | |
| SCHEMBL13333240 | 0.66 | PDE4A (0.73) | PDE4APDE5APDE3BPDE11APDE7B | |
| SCHEMBL16977200 | 0.65 | MDM2 (0.42) | PDE4APDE5APDE3BPDE11APDE7B | |
| SCHEMBL16977232 | 0.65 | SYK (0.40) | SYKCHRM1KCNH2JAK2JAK1 | |
| SCHEMBL16977204 | 0.64 | CHRM1 (0.36) | CHRM1KCNH2JAK2JAK1TYK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2358204-B1 | 4,5,7,8-tetrahydro-4-oxo-2H-imidazo[1,2-a]pyrrolo[3,4-e]pyrimidine compounds as PDE1 inhibitors. | INTRA CELLULAR THERAPIES INC (US) | 2015-08-05 | — | — | EP | disclosed |