Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 14/20 | 0.40 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.37 |
| ▸ | JAK2 | O60674 | 1/20 | 0.36 |
| ▸ | JAK1 | P23458 | 1/20 | 0.36 |
| ▸ | TYK2 | P29597 | 1/20 | 0.36 |
| ▸ | JAK3 | P52333 | 1/20 | 0.36 |
| ▸ | CHRM1 | P11229 | 3/20 | 0.34 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16977213 | 0.77 | SYK (0.51) | SYK | |
| SCHEMBL16977200 | 0.69 | MDM2 (0.42) | SYK | |
| SCHEMBL13333215 | 0.67 | PDE4A (0.46) | PDE1B | |
| SCHEMBL16977207 | 0.66 | PDE5A (0.36) | — | |
| SCHEMBL16977212 | 0.65 | PDE4A (0.42) | SYKKCNH2JAK2JAK1TYK2 | |
| SCHEMBL16977239 | 0.64 | SYK (0.46) | SYKCHRM1 | |
| SCHEMBL13333460 | 0.61 | SYK (0.43) | SYKCHRM1PDE1B | |
| SCHEMBL12281182 | 0.60 | PDE4A (0.47) | PDE1B | |
| SCHEMBL16977211 | 0.59 | SYK (0.38) | SYKJAK3 | |
| SCHEMBL17359641 | 0.55 | LMNA (0.42) | KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2358204-B1 | 4,5,7,8-tetrahydro-4-oxo-2H-imidazo[1,2-a]pyrrolo[3,4-e]pyrimidine compounds as PDE1 inhibitors. | INTRA CELLULAR THERAPIES INC (US) | 2015-08-05 | — | — | EP | disclosed |