Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | AR | P10275 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.35 |
| ▸ | POLB | P06746 | 2/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
| ▸ | ALPL | P05186 | 2/20 | 0.35 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.35 |
| ▸ | KDR | P35968 | 1/20 | 0.35 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.35 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | STAT3 | P40763 | 1/20 | 0.34 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18560457 | 0.81 | KDM4C (0.65) | KDM4CALDH1A1HSD17B10GAAAR | |
| SCHEMBL7902863 | 0.80 | KDM4C (0.53) | KDM4CALDH1A1HSD17B10GAAAR | |
| SCHEMBL23115860 | 0.78 | KDM4C (0.67) | KDM4CALDH1A1HSD17B10GAAAR | |
| SCHEMBL23294471 | 0.77 | KDM4C (0.50) | KDM4CALDH1A1HSD17B10GAAAR | |
| SCHEMBL11204987 | 0.74 | KDM4C (0.47) | KDM4CALDH1A1HSD17B10GAAAR | |
| SCHEMBL171417 | 0.73 | KDM4C (0.46) | KDM4CALDH1A1HSD17B10GAAAR | |
| SCHEMBL30975958 | 0.72 | ALDH1A1 (0.44) | KDM4CALDH1A1HSD17B10MAPK1LMNA | |
| SCHEMBL30976062 | 0.72 | KDM4C (0.41) | KDM4CALDH1A1HSD17B10MAPK1LMNA | |
| SCHEMBL30976137 | 0.71 | KDM4C (0.41) | KDM4CALDH1A1HSD17B10MAPK1LMNA | |
| SCHEMBL30975871 | 0.71 | KDM4C (0.41) | KDM4CALDH1A1HSD17B10MAPK1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118930533-A | Substituted pyrazole compounds and methods of using the same for treating hyperproliferative diseases | 班塔姆制药有限责任公司 | 2024-11-12 | — | — | CN | disclosed |
| CN-110603254-B | Substituted pyrazole compounds and methods of using the same for treating hyperproliferative diseases | 班塔姆制药有限责任公司 | 2024-04-12 | — | — | CN | disclosed |
| EP-2426110-A1 | PYRAZOLYL ACRYLONITRILE COMPOUNDS AND USES THEREOF | Sinochem Corporation (CN) | 2012-03-07 | — | — | EP | disclosed |