Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 20/20 | 0.86 |
| ▸ | SLCO1B1 | Q9Y6L6 | 1/20 | 0.78 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31757156 | 0.92 | LRRK2 (1.00) | LRRK2SLCO1B1 | |
| SCHEMBL18018893 | 0.92 | LRRK2 (1.00) | LRRK2SLCO1B1 | |
| SCHEMBL18395067 | 0.91 | LRRK2 (0.82) | LRRK2SLCO1B1 | |
| SCHEMBL16982511 | 0.88 | LRRK2 (1.00) | LRRK2SLCO1B1 | |
| SCHEMBL17980630 | 0.86 | LRRK2 (0.81) | LRRK2 | |
| SCHEMBL16982526 | 0.85 | LRRK2 (0.72) | LRRK2SLCO1B1 | |
| SCHEMBL24556852 | 0.84 | LRRK2 (0.77) | LRRK2SLCO1B1 | |
| SCHEMBL7451422 | 0.84 | LRRK2 (0.86) | LRRK2SLCO1B1 | |
| SCHEMBL7451347 | 0.83 | LRRK2 (0.86) | LRRK2SLCO1B1 | |
| SCHEMBL16982465 | 0.83 | LRRK2 (0.91) | LRRK2SLCO1B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3099694-B1 | COMPOUNDS | GLAXOSMITHKLINE IP DEV LTD (GB) | 2019-01-16 | — | — | EP | claimed |
| US-9815841-B2 | Compounds | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2017-11-14 | — | — | US | claimed |
| US-20220204515-A1 | PYRROLOPYRIMIDINE INHIBITORS OF WILD-TYPE AND MUTANT FORMS OF LRRK2 | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2022-06-30 | — | — | US | disclosed |
| EP-3099694-B1 | COMPOUNDS | GLAXOSMITHKLINE IP DEV LTD (GB) | 2019-01-16 | — | — | EP | disclosed |
| EP-3099694-B1 | COMPOUNDS | GLAXOSMITHKLINE IP DEV LTD (GB) | 2019-01-16 | — | — | EP | disclosed |
| US-9815841-B2 | Compounds | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2017-11-14 | — | — | US | disclosed |
| US-9815841-B2 | Compounds | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2017-11-14 | — | — | US | disclosed |
| US-9815841-B2 | Compounds | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2017-11-14 | — | — | US | disclosed |
| US-20170022204-A1 | COMPOUNDS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2017-01-26 | — | — | US | disclosed |
| US-20170022204-A1 | COMPOUNDS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2017-01-26 | — | — | US | disclosed |
| US-20170022204-A1 | COMPOUNDS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2017-01-26 | — | — | US | disclosed |
| WO-2015113451-A1 | COMPOUNDS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2015-08-06 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170022204-A1 | COMPOUNDS | LRRK2, PARK7, PINK1 | LRRK2 1/4885SLCO1B1 4733/4885 |
| US-20220204515-A1 | PYRROLOPYRIMIDINE INHIBITORS OF WILD-TYPE AND MUTANT FORMS OF LRRK2 | LRRK2, PARK7, PINK1 | LRRK2 1/4885SLCO1B1 4526/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.