Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP3K5 | Q99683 | 16/20 | 0.42 |
| ▸ | ABL1 | P00519 | 1/20 | 0.36 |
| ▸ | PRKCI | P41743 | 1/20 | 0.36 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.36 |
| ▸ | AKT1 | P31749 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL232606 | 0.81 | MAP3K5 (0.55) | MAP3K5 | |
| SCHEMBL27912225 | 0.73 | MYC (0.47) | MAP3K5PDE10A | |
| SCHEMBL1083047 | 0.72 | MAP3K5 (0.72) | MAP3K5 | |
| SCHEMBL230744 | 0.70 | MAP3K5 (0.57) | MAP3K5 | |
| SCHEMBL29949085 | 0.66 | MAP3K5 (0.41) | MAP3K5 | |
| SCHEMBL1698790 | 0.63 | MAP3K5 (0.42) | MAP3K5 | |
| SCHEMBL231811 | 0.63 | ALDH1A1 (0.54) | — | |
| SCHEMBL28987763 | 0.62 | MAP3K5 (0.37) | MAP3K5 | |
| SCHEMBL10220573 | 0.62 | MAP3K5 (0.46) | MAP3K5 | |
| SCHEMBL28987796 | 0.61 | GRM5 (0.39) | MAP3K5AKT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2588475-A1 | APOPTOSIS SIGNAL-REGULATING KINASE INHIBITORS | Gilead Sciences, Inc. (US) | 2013-05-08 | — | — | EP | disclosed |
| WO-2012003387-A1 | APOPTOSIS SIGNAL-REGULATING KINASE INHIBITORS | GILEAD SCIENCES, INC. (US) | 2012-01-05 | — | — | WO | disclosed |