Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.44 |
| ▸ | PDE9A | O76083 | 4/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 7/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.39 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | FPR1 | P21462 | 1/20 | 0.39 |
| ▸ | FPR2 | P25090 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | XBP1 | P17861 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16986351 | 0.87 | GSK3B (0.41) | KDM4EALDH1A1MAPTGAAHPGD | |
| SCHEMBL16986329 | 0.72 | TP53 (0.37) | KDM4EALDH1A1MAPTGAASMN1; SMN2 | |
| SCHEMBL16986319 | 0.72 | KDM4C (0.37) | KDM4EMAPTTDP1LMNA | |
| SCHEMBL16986300 | 0.68 | TP53 (0.37) | KDM4EALDH1A1MAPTGAATDP1 | |
| SCHEMBL16986343 | 0.67 | KDM4E (0.55) | KDM4EPDE9AALDH1A1MAPTGAA | |
| SCHEMBL866356 | 0.63 | MAPT (0.77) | KDM4EALDH1A1MAPTGAAHPGD | |
| SCHEMBL16986306 | 0.63 | NOS1 (0.39) | LMNA | |
| SCHEMBL16986314 | 0.61 | TLR7 (0.40) | KCNH2 | |
| SCHEMBL28661976 | 0.60 | DDB1 (0.46) | KDM4EALDH1A1DDB1CRBNSMN1; SMN2 | |
| SCHEMBL28661979 | 0.60 | DDB1 (0.46) | KDM4EALDH1A1DDB1CRBNSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2905024-A1 | Pyrido[2,3-d]pyrimidine-7(8H)-one derivatives for the treatment of infections caused by Flaviviridae | Institut Quimic De Sarriá Cets, Fundació Privada (ES) | 2015-08-12 | — | — | EP | disclosed |
| EP-2905024-A1 | Pyrido[2,3-d]pyrimidine-7(8H)-one derivatives for the treatment of infections caused by Flaviviridae | Institut Quimic De Sarriá Cets, Fundació Privada (ES) | 2015-08-12 | — | — | EP | disclosed |