SCHEMBL866356

SCHEMBL866356

COc1ccc(Nc2ccc(F)cc2)cc1

nearest known ligand 0.77

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 6/20 0.77
GAA P10253 5/20 0.77
KDM4E B2RXH2 4/20 0.77
RAB9A P51151 2/20 0.77
MAPK1 P28482 2/20 0.77
L3MBTL1 Q9Y468 2/20 0.77
TDP1 Q9NUW8 2/20 0.77
NPC1 O15118 1/20 0.77
THRB P10828 1/20 0.77
RECQL P46063 1/20 0.77
NPSR1 Q6W5P4 1/20 0.77
MAOA P21397 2/20 0.63
MAOB P27338 2/20 0.63
NR4A1 P22736 1/20 0.63
NFE2L2 Q16236 1/20 0.57
ALDH1A1 P00352 4/20 0.55
HTT P42858 2/20 0.55
MEN1 O00255 3/20 0.54
KMT2A Q03164 3/20 0.54
HPGD P15428 2/20 0.54

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL19660767 0.94 MAPT (0.68) MAPTGAAKDM4ERAB9AMAPK1
SCHEMBL39057 0.88 MAPT (1.00) MAPTGAAKDM4ERAB9AMAPK1
SCHEMBL1459772 0.88 MAPT (1.00) MAPTGAAKDM4ERAB9AMAPK1
SCHEMBL7024215 0.85
SCHEMBL8298 0.85
SCHEMBL7844969 0.82 MTNR1B (0.64) MAPTGAAKDM4ERAB9AMAPK1
SCHEMBL1921511 0.81 MAPT (0.85) MAPTGAAKDM4ERAB9AMAPK1
SCHEMBL7758813 0.81 RAB9A (0.85) MAPTGAAKDM4ERAB9AMAPK1
SCHEMBL12648780 0.81 MAPT (0.85) MAPTGAAKDM4ERAB9AMAPK1
SCHEMBL8943931 0.81 MAPT (0.85) MAPTGAAKDM4ERAB9AMAPK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 76 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12410364-B2 Electrochromic composition and electrochromic device TAI YING OPTRONICS CO., LTD. (TW) 2025-09-09 US disclosed
CN-117925215-A Electrochromic composition and electrochromic device 泰盈光电股份有限公司 2024-04-26 CN disclosed
US-20240085753-A1 ELECTROCHROMIC COMPOSITION AND ELECTROCHROMIC DEVICE TAI YING OPTRONICS CO., LTD. (TW) 2024-03-14 US disclosed
US-11572348-B2 Syntheses of N-heterocyclic carbenes and intermediates therefor UMICORE AG & CO. KG (DE) 2023-02-07 US disclosed
US-20230009845-A1 ORGANIC ELECTRIC ELEMENT COMPRISING A PLURALITY OF EMISSION-AUXILIARY LAYERS AND ELECTRONIC DEVICE COMPRISING IT DUK SAN NEOLUX CO., LTD. (KR) 2023-01-12 US disclosed
US-11205755-B2 Compound for organic electronic element, organic electronic element using same, and electronic device thereof DUK SAN NEOLUX CO., LTD. (KR) 2021-12-21 US disclosed
US-20210317088-A9 SYNTHESES OF N-HETEROCYCLIC CARBENES AND INTERMEDIATES THEREFOR UMICORE AG & CO. KG (DE) 2021-10-14 US disclosed
US-20200354323-A1 SYNTHESES OF N-HETEROCYCLIC CARBENES AND INTERMEDIATES THEREFOR UMICORE AG & CO. KG (DE) 2020-11-12 US disclosed
US-10759763-B2 Syntheses of N-heterocyclic carbenes and intermediates therefor UMICORE AG & CO. KG (DE) 2020-09-01 US disclosed
US-20190296248-A1 COMPOUND FOR ORGANIC ELECTRONIC ELEMENT, ORGANIC ELECTRONIC ELEMENT USING SAME AND ELECTRONIC DEVICE THEREFOR DUK SAN NEOLUX CO., LTD. (KR) 2019-09-26 US disclosed
US-20090221820-A1 Ligands for Transition-Metal-Catalyzed Cross-Couplings, and Methods of Use Thereof MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) 2009-09-03 US disclosed
US-20090221820-A1 Ligands for Transition-Metal-Catalyzed Cross-Couplings, and Methods of Use Thereof MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) 2009-09-03 US disclosed
WO-2009076622-A2 LIGANDS FOR TRANSITION-METAL-CATALYZED CROSS-COUPLINGS, AND METHODS OF USE THEREOF MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) 2009-06-18 WO disclosed
US-20090062341-A1 Nuclear receptor binding agents GTX, INC 2009-03-05 US disclosed
US-20070265296-A1 Nuclear receptor binding agents GTX, INC. 2007-11-15 US disclosed
EP-0731091-B1 2-OXOINDOLINE DERIVATIVES AS CHOLECYSTOKININ RECEPTOR ANTAGONISTS TANABE SEIYAKU CO (JP) 2002-01-02 EP disclosed
US-5807883-A GASTROINTESTINAL DISORDERS; PANCREATITIS TANABE SEIYAKU CO., LTD. (JP) 1998-09-15 US disclosed
EP-0731091-A1 2-OXOINDOLINE DERIVATIVE TANABE SEIYAKU CO., LTD. (JP) 1996-09-11 EP disclosed
US-5434148-A β-carboline derivative TANABE SEIYAKU CO., LTD. (JP) 1995-07-18 US disclosed
EP-0572235-A2 Beta-carboline derivatives with anticholecystoquinine activity TANABE SEIYAKU CO., LTD. (JP) 1993-12-01 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10759763-B2 Syntheses of N-heterocyclic carbenes and intermediates therefor GRHPR, DDC, NDC1 MAPT 3063/4885GAA 3601/4885KDM4E 3800/4885
US-20070265296-A1 Nuclear receptor binding agents GPER1, ESRRG, ESR2 MAPT 869/4885GAA 4352/4885KDM4E 1462/4885
US-11572348-B2 Syntheses of N-heterocyclic carbenes and intermediates therefor GRHPR, DDC, NDC1 MAPT 3063/4885GAA 3601/4885KDM4E 3800/4885
US-20090062341-A1 Nuclear receptor binding agents GPER1, ESRRG, ESR2 MAPT 869/4885GAA 4352/4885KDM4E 1462/4885
US-20210317088-A9 SYNTHESES OF N-HETEROCYCLIC CARBENES AND INTERMEDIATES THEREFOR GRHPR, DDC, NDC1 MAPT 3063/4885GAA 3601/4885KDM4E 3800/4885
US-20200354323-A1 SYNTHESES OF N-HETEROCYCLIC CARBENES AND INTERMEDIATES THEREFOR GRHPR, DDC, NDC1 MAPT 3063/4885GAA 3601/4885KDM4E 3800/4885
US-20090221820-A1 Ligands for Transition-Metal-Catalyzed Cross-Couplings, and Methods of Use Thereof SOD1, TIMCC, TST MAPT 3058/4885GAA 1562/4885KDM4E 4308/4885
US-11205755-B2 Compound for organic electronic element, organic electronic element using same, and electronic device thereof PIEZO1, OR51E2, ORAI2 MAPT 1224/4885GAA 3607/4885KDM4E 585/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.