Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK1 | P23458 | 7/20 | 0.46 |
| ▸ | JAK2 | O60674 | 12/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | MAP3K5 | Q99683 | 1/20 | 0.40 |
| ▸ | TYK2 | P29597 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13031187 | 0.85 | JAK1 (0.66) | JAK1JAK2TYK2 | |
| Cyclopropane SCHEMBL16986950 | 0.78 | JAK1 (0.70) | JAK1JAK2MAP3K5TYK2 | |
| SCHEMBL25310876 | 0.72 | JAK1 (0.48) | JAK1JAK2MAP3K5TYK2 | |
| SCHEMBL3104863 | 0.72 | NUDT1 (0.54) | JAK1LMNASMN1; SMN2 | |
| Cyclopropane SCHEMBL16986945 | 0.70 | MAP3K5 (0.73) | JAK1JAK2MAP3K5TYK2 | |
| Cyclopropane SCHEMBL16986941 | 0.69 | JAK1 (0.73) | JAK1JAK2TYK2 | |
| Cyclopropane SCHEMBL15653061 | 0.68 | JAK3 (0.57) | JAK1JAK2TYK2 | |
| Cyclopropane SCHEMBL16986951 | 0.67 | JAK2 (0.55) | JAK1JAK2TYK2 | |
| Cyclopropane SCHEMBL15654624 | 0.66 | JAK1 (0.76) | JAK1JAK2TYK2 | |
| SCHEMBL13465775 | 0.63 | JAK2 (0.79) | JAK1JAK2MAP3K5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2057158-B1 | TRIAZOLE DERIVATIVES AS KINASE INHIBITORS | CELLZOME LTD (GB) | 2015-08-12 | — | — | EP | claimed |