Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKT1 | P31749 | 18/20 | 0.47 |
| ▸ | RPS6KB1 | P23443 | 17/20 | 0.47 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16987151 | 0.80 | AKT1 (0.62) | AKT1RPS6KB1 | |
| SCHEMBL4239895 | 0.79 | P2RY14 (0.41) | AKT1RPS6KB1SOS1 | |
| SCHEMBL16241659 | 0.79 | RPS6KB1 (0.74) | AKT1RPS6KB1 | |
| Hydrochloric Acid SCHEMBL311632 | 0.78 | P2RY14 (0.41) | AKT1RPS6KB1SOS1 | |
| SCHEMBL27796918 | 0.77 | SOS1 (0.45) | AKT1RPS6KB1SOS1 | |
| Hydrochloric Acid SCHEMBL15732670 | 0.76 | SOS1 (0.45) | AKT1RPS6KB1SOS1 | |
| SCHEMBL2063570 | 0.76 | APP (0.39) | AKT1RPS6KB1SOS1 | |
| SCHEMBL14782637 | 0.75 | RPS6KB1 (0.59) | AKT1RPS6KB1 | |
| Hydrochloric Acid SCHEMBL2062816 | 0.75 | APP (0.39) | AKT1RPS6KB1SOS1 | |
| Hydrochloric Acid SCHEMBL14782585 | 0.74 | RPS6KB1 (0.58) | AKT1RPS6KB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9434714-B2 | Pyrimidine imidazole amines as modulators of kinase activity | MERCK PATENT GMBH (DE) | 2016-09-06 | — | — | US | disclosed |
| US-20150225371-A1 | Novel Pyrimidine Imidazole Amines as Modulators of Kinase Activity | MERCK PATENT GMBH (DE) | 2015-08-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150225371-A1 | Novel Pyrimidine Imidazole Amines as Modulators of Kinase Activity | TK1, CHEK2, DCK | AKT1 397/4885RPS6KB1 336/4885SOS1 1996/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.