Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FLT3 | P36888 | 13/20 | 0.55 |
| ▸ | CSF1R | P07333 | 11/20 | 0.55 |
| ▸ | PDGFRB | P09619 | 3/20 | 0.54 |
| ▸ | KIT | P10721 | 3/20 | 0.54 |
| ▸ | PDGFRA | P16234 | 3/20 | 0.54 |
| ▸ | RAF1 | P04049 | 1/20 | 0.46 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.46 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.41 |
| ▸ | NTRK3 | Q16288 | 1/20 | 0.41 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.41 |
| ▸ | RET | P07949 | 1/20 | 0.39 |
| ▸ | EPHB2 | P29323 | 1/20 | 0.39 |
| ▸ | KDR | P35968 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1698717 | 0.95 | FLT3 (0.52) | FLT3CSF1RPDGFRBKITPDGFRA | |
| SCHEMBL15388274 | 0.91 | FLT3 (0.54) | FLT3CSF1RPDGFRBKITPDGFRA | |
| SCHEMBL1698798 | 0.87 | FLT3 (0.73) | FLT3CSF1RPDGFRBKITPDGFRA | |
| SCHEMBL1698962 | 0.86 | FLT3 (0.71) | FLT3CSF1RPDGFRBKITPDGFRA | |
| SCHEMBL1698764 | 0.84 | FLT3 (0.75) | FLT3CSF1RPDGFRBKITPDGFRA | |
| SCHEMBL15388779 | 0.84 | FLT3 (0.55) | FLT3CSF1RPDGFRBKITPDGFRA | |
| SCHEMBL1698582 | 0.84 | FLT3 (0.72) | FLT3CSF1RPDGFRBKITPDGFRA | |
| SCHEMBL1698946 | 0.83 | FLT3 (0.62) | FLT3CSF1RPDGFRBKITPDGFRA | |
| SCHEMBL1699023 | 0.83 | FLT3 (0.53) | FLT3CSF1RPDGFRBKITPDGFRA | |
| SCHEMBL1698736 | 0.83 | FLT3 (0.63) | FLT3CSF1RPDGFRBKITPDGFRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9296722-B2 | Azolyl urea compounds and methods of use thereof | AMBIT BIOSCIENCES CORPORATION (US) | 2016-03-29 | — | — | US | claimed |
| US-20130310357-A1 | Azolyl Urea Compounds and Methods of Use Thereof | AMBIT BIOSCIENCES CORPORATION (US) | 2013-11-21 | — | — | US | claimed |
| US-9296722-B2 | Azolyl urea compounds and methods of use thereof | AMBIT BIOSCIENCES CORPORATION (US) | 2016-03-29 | — | — | US | disclosed |
| US-20130310357-A1 | Azolyl Urea Compounds and Methods of Use Thereof | AMBIT BIOSCIENCES CORPORATION (US) | 2013-11-21 | — | — | US | disclosed |
| WO-2011150198-A1 | AZOLYL UREA COMPOUNDS AND METHODS OF USE THEREOF | AMBIT BIOSCIENCES CORPORATION (US) | 2011-12-01 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130310357-A1 | Azolyl Urea Compounds and Methods of Use Thereof | CSF1R, CSF3R, ARG1 | FLT3 4/4885CSF1R 1/4885PDGFRB 733/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.