Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 5/20 | 0.58 |
| ▸ | RAB9A | P51151 | 5/20 | 0.58 |
| ▸ | NCF1 | P14598 | 1/20 | 0.55 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.52 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.52 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.48 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.48 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.46 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | PDE10A | Q9Y233 | 3/20 | 0.41 |
| ▸ | SSTR3 | P32745 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1708932 | 1.00 | NPC1 (0.58) | NPC1RAB9ANCF1DDB1CRBN | |
| SCHEMBL16666168 | 0.87 | NPC1 (0.56) | NPC1RAB9ANCF1DDB1CRBN | |
| SCHEMBL9056686 | 0.86 | NPC1 (0.59) | NPC1RAB9ANCF1DDB1CRBN | |
| Hydrochloric Acid SCHEMBL8852766 | 0.84 | NPC1 (0.57) | NPC1RAB9ANCF1DDB1CRBN | |
| SCHEMBL24092000 | 0.84 | MCHR1 (0.57) | NPC1RAB9ANCF1DDB1CRBN | |
| SCHEMBL29911218 | 0.84 | MCHR1 (0.57) | NPC1RAB9ANCF1DDB1CRBN | |
| SCHEMBL31620776 | 0.83 | NCF1 (0.57) | NPC1RAB9ANCF1DDB1CRBN | |
| SCHEMBL1708938 | 0.81 | NPC1 (0.42) | NPC1RAB9ANCF1DDB1CRBN | |
| SCHEMBL1699014 | 0.81 | NPC1 (0.42) | NPC1RAB9ANCF1DDB1CRBN | |
| SCHEMBL12723436 | 0.81 | NPC1 (0.50) | NPC1RAB9ANCF1DDB1CRBN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9399652-B2 | Synthetic route to pactamycin and pactamycin analogs | THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) | 2016-07-26 | — | — | US | disclosed |
| US-9399652-B2 | Synthetic route to pactamycin and pactamycin analogs | THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) | 2016-07-26 | — | — | US | disclosed |
| US-20150329570-A1 | SYNTHETIC ROUTE TO PACTAMYCIN AND PACTAMYCIN ANALOGS | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2015-11-19 | — | — | US | disclosed |
| US-20150329570-A1 | SYNTHETIC ROUTE TO PACTAMYCIN AND PACTAMYCIN ANALOGS | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2015-11-19 | — | — | US | disclosed |
| US-8889863-B2 | Stereoselective methods, catalysts and intermediates for the synthesis of (−)-Nutlin-3 and related compounds | VANDERBILT UNIVERSITY (US) | 2014-11-18 | — | — | US | disclosed |
| US-8889863-B2 | Stereoselective methods, catalysts and intermediates for the synthesis of (−)-Nutlin-3 and related compounds | VANDERBILT UNIVERSITY (US) | 2014-11-18 | — | — | US | disclosed |
| US-20120088915-A1 | STEREOSELECTIVE METHODS, CATALYSTS AND INTERMEDIATES FOR THE SYNTHESIS OF (-)-NUTLIN-3 AND RELATED COMPOUNDS | VANDERBILT UNIVERSITY | 2012-04-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150329570-A1 | SYNTHETIC ROUTE TO PACTAMYCIN AND PACTAMYCIN ANALOGS | PAICS, DPM1, MANBA | NPC1 3126/4885RAB9A 1256/4885NCF1 2477/4885 |
| US-20120088915-A1 | STEREOSELECTIVE METHODS, CATALYSTS AND INTERMEDIATES FOR THE SYNTHESIS OF (-)-NUTLIN-3 AND RELATED COMPOUNDS | NUTF2, MDM2, CIAPIN1 | NPC1 2645/4885RAB9A 3389/4885NCF1 268/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.