Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCHR1 | Q99705 | 1/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.55 |
| ▸ | LMNA | P02545 | 1/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.55 |
| ▸ | NCF1 | P14598 | 1/20 | 0.53 |
| ▸ | NPC1 | O15118 | 2/20 | 0.53 |
| ▸ | RAB9A | P51151 | 2/20 | 0.53 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.51 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.51 |
| ▸ | PDE10A | Q9Y233 | 4/20 | 0.47 |
| ▸ | MAOB | P27338 | 1/20 | 0.47 |
| ▸ | CXCR3 | P49682 | 1/20 | 0.47 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.44 |
| ▸ | CTSK | P43235 | 1/20 | 0.44 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.42 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.42 |
| ▸ | PDE5A | O76074 | 2/20 | 0.42 |
| ▸ | ACP1 | P24666 | 2/20 | 0.42 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29911218 | 1.00 | MCHR1 (0.57) | MCHR1KDM4ELMNASMN1; SMN2NCF1 | |
| SCHEMBL16666168 | 0.96 | NPC1 (0.56) | MCHR1KDM4ELMNASMN1; SMN2NCF1 | |
| SCHEMBL9056686 | 0.95 | NPC1 (0.59) | MCHR1KDM4ELMNASMN1; SMN2NCF1 | |
| Hydrochloric Acid SCHEMBL8852766 | 0.93 | NPC1 (0.57) | MCHR1KDM4ELMNASMN1; SMN2NCF1 | |
| SCHEMBL31620776 | 0.93 | NCF1 (0.57) | MCHR1KDM4ELMNASMN1; SMN2NCF1 | |
| SCHEMBL5943465 | 0.86 | MCHR1 (0.56) | MCHR1KDM4ELMNASMN1; SMN2NCF1 | |
| SCHEMBL5943499 | 0.85 | NCF1 (0.49) | MCHR1KDM4ELMNASMN1; SMN2NCF1 | |
| SCHEMBL30824493 | 0.85 | PDE10A (0.59) | MCHR1KDM4ELMNASMN1; SMN2NCF1 | |
| SCHEMBL7698523 | 0.85 | NPC1 (0.49) | MCHR1NCF1NPC1RAB9ADDB1 | |
| SCHEMBL6456504 | 0.85 | NCF1 (0.49) | MCHR1KDM4ELMNASMN1; SMN2NCF1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11952380-B2 | Substituted bicyclic heterocyclic compounds as PRMT5 inhibitors | LUPIN LIMITED (IN) | 2024-04-09 | — | — | US | disclosed |
| US-11198699-B2 | Compounds targeting PRMT5 | ALIGOS THERAPEUTICS, INC. (US) | 2021-12-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11198699-B2 | Compounds targeting PRMT5 | PRMT5, PRMT1, PRMT6 | MCHR1 2833/4885KDM4E 47/4885LMNA 2624/4885 |
| US-11952380-B2 | Substituted bicyclic heterocyclic compounds as PRMT5 inhibitors | PRMT5, PRMT1, PRMT3 | MCHR1 3974/4885KDM4E 47/4885LMNA 2045/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.