Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 2/20 | 0.49 |
| ▸ | GAA | P10253 | 2/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | EPHX2 | P34913 | 6/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26140448 | 0.96 | L3MBTL1 (0.47) | MAPK1GAATDP1ALDH1A1RAB9A | |
| SCHEMBL10205067 | 0.93 | POLB (0.48) | MAPK1GAAALDH1A1RAB9AEPHX2 | |
| SCHEMBL21569681 | 0.90 | L3MBTL1 (0.43) | MAPK1GAATDP1ALDH1A1RAB9A | |
| SCHEMBL18944154 | 0.89 | L3MBTL1 (0.53) | MAPK1GAAALDH1A1RAB9AEPHX2 | |
| SCHEMBL18745367 | 0.89 | ALDH1A1 (0.43) | MAPK1GAATDP1ALDH1A1RAB9A | |
| SCHEMBL26139034 | 0.89 | EPHX2 (0.45) | MAPK1GAATDP1ALDH1A1RAB9A | |
| SCHEMBL21569624 | 0.86 | GAA (0.40) | MAPK1GAATDP1ALDH1A1RAB9A | |
| SCHEMBL20348488 | 0.85 | TSHR (0.42) | MAPK1GAAALDH1A1RAB9AEPHX2 | |
| SCHEMBL21569747 | 0.84 | SSTR4 (0.41) | MAPK1GAAALDH1A1RAB9AEPHX2 | |
| SCHEMBL2146241 | 0.83 | ALDH1A1 (0.51) | MAPK1GAAALDH1A1RAB9AEPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3102568-A1 | BICYCLIC AZA COMPOUNDS AS MUSCARINIC M1 RECEPTOR AND/OR M4 RECEPTOR AGONISTS | Heptares Therapeutics Limited (GB) | 2016-12-14 | — | — | EP | disclosed |
| WO-2015118342-A1 | BICYCLIC AZA COMPOUNDS AS MUSCARINIC M1 RECEPTOR AGONISTS. | HEPTARES THERAPEUTICS LIMITED (GB) | 2015-08-13 | — | — | WO | disclosed |