Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 15/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 15/20 | 0.53 |
| ▸ | CYP2C19 | P33261 | 13/20 | 0.53 |
| ▸ | TSHR | P16473 | 13/20 | 0.53 |
| ▸ | CYP2D6 | P10635 | 13/20 | 0.53 |
| ▸ | CLK4 | Q9HAZ1 | 7/20 | 0.53 |
| ▸ | LMNA | P02545 | 5/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.53 |
| ▸ | GLA | P06280 | 1/20 | 0.53 |
| ▸ | USP2 | O75604 | 8/20 | 0.52 |
| ▸ | MEN1 | O00255 | 4/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.48 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.48 |
| ▸ | APLNR | P35414 | 1/20 | 0.48 |
| ▸ | ALOX15 | P16050 | 5/20 | 0.47 |
| ▸ | CASP7 | P55210 | 1/20 | 0.47 |
| ▸ | CA1 | P00915 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16992915 | 0.91 | KDM4C (0.54) | CYP1A2CYP3A4CYP2C19TSHRCYP2D6 | |
| SCHEMBL31118682 | 0.87 | CYP1A2 (0.53) | CYP1A2CYP3A4CYP2C19TSHRCYP2D6 | |
| SCHEMBL3717932 | 0.83 | ALDH1A1 (0.57) | CLK4ALDH1A1CA1CA2MAPT | |
| SCHEMBL17149371 | 0.83 | TSHR (0.49) | CYP1A2CYP3A4CYP2C19TSHRCYP2D6 | |
| SCHEMBL28091611 | 0.82 | CYP1A2 (0.58) | CYP1A2CYP3A4CYP2C19TSHRCYP2D6 | |
| SCHEMBL20092723 | 0.82 | CYP1A2 (0.55) | CYP1A2CYP3A4CYP2C19TSHRCYP2D6 | |
| SCHEMBL23981519 | 0.81 | CYP1A2 (0.52) | CYP1A2CYP3A4CYP2C19TSHRCYP2D6 | |
| SCHEMBL30273296 | 0.81 | CYP1A2 (0.52) | CYP1A2CYP3A4CYP2C19TSHRCYP2D6 | |
| SCHEMBL30397014 | 0.81 | CYP1A2 (0.52) | CYP1A2CYP3A4CYP2C19TSHRCYP2D6 | |
| SCHEMBL2135922 | 0.80 | KDM4C (0.52) | CYP1A2CYP3A4CYP2C19TSHRCYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11078193-B2 | Sulphamoylpyrrolamide derivatives and the use thereof as medicaments for the treatment of hepatitis B | JANSSEN SCIENCES IRELAND UC (IE) | 2021-08-03 | — | — | US | disclosed |
| EP-3102572-B1 | SULPHAMOYLPYRROLAMIDE DERIVATIVES AND THE USE THEREOF AS MEDICAMENTS FOR THE TREATMENT OF HEPATITIS B | JANSSEN SCIENCES IRELAND UC (IE) | 2018-10-24 | — | — | EP | disclosed |
| EP-3102572-A1 | SULPHAMOYLPYRROLAMIDE DERIVATIVES AND THE USE THEREOF AS MEDICAMENTS FOR THE TREATMENT OF HEPATITIS B | Janssen Sciences Ireland UC (IE) | 2016-12-14 | — | — | EP | disclosed |
| US-20160347741-A1 | SULPHAMOYLPYRROLAMIDE DERIVATIVES AND THE USE THEREOF AS MEDICAMENTS FOR THE TREATMENT OF HEPATITIS B | JANSSEN SCIENCES IRELAND UC | 2016-12-01 | — | — | US | disclosed |
| WO-2015118057-A1 | SULPHAMOYLPYRROLAMIDE DERIVATIVES AND THE USE THEREOF AS MEDICAMENTS FOR THE TREATMENT OF HEPATITIS B | JANSSEN SCIENCES IRELAND UC (IE) | 2015-08-13 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11078193-B2 | Sulphamoylpyrrolamide derivatives and the use thereof as medicaments for the treatment of hepatitis B | RB1, SRR, RRP12 | CYP1A2 1169/4885CYP3A4 516/4885CYP2C19 1904/4885 |
| US-20160347741-A1 | SULPHAMOYLPYRROLAMIDE DERIVATIVES AND THE USE THEREOF AS MEDICAMENTS FOR THE TREATMENT OF HEPATITIS B | RB1, SRR, RRP12 | CYP1A2 1169/4885CYP3A4 516/4885CYP2C19 1904/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.