Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 1/20 | 1.00 |
| ▸ | MEN1 | O00255 | 1/20 | 0.90 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.90 |
| ▸ | MAPT | P10636 | 6/20 | 0.76 |
| ▸ | POLB | P06746 | 5/20 | 0.76 |
| ▸ | ATM | Q13315 | 3/20 | 0.76 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.76 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.76 |
| ▸ | PAX8 | Q06710 | 3/20 | 0.74 |
| ▸ | LMNA | P02545 | 3/20 | 0.72 |
| ▸ | HPGD | P15428 | 1/20 | 0.72 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.72 |
| ▸ | NPC1 | O15118 | 2/20 | 0.71 |
| ▸ | HTT | P42858 | 4/20 | 0.69 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.69 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.65 |
| ▸ | THRB | P10828 | 1/20 | 0.65 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.65 |
| ▸ | GAA | P10253 | 1/20 | 0.65 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.65 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12008983 | 0.86 | POLB (1.00) | RAB9AMEN1KMT2AMAPTPOLB | |
| SCHEMBL12008795 | 0.84 | MEN1 (0.78) | RAB9AMEN1KMT2AMAPTPOLB | |
| SCHEMBL12008805 | 0.83 | KMT2A (0.79) | RAB9AMEN1KMT2AMAPTPOLB | |
| SCHEMBL12008779 | 0.80 | KMT2A (0.90) | RAB9AMEN1KMT2AMAPTPOLB | |
| SCHEMBL12008878 | 0.80 | POLB (0.90) | RAB9AMEN1KMT2AMAPTPOLB | |
| SCHEMBL12008428 | 0.80 | PLA2G1B (0.74) | RAB9AMAPTPOLBMAPK1LMNA | |
| SCHEMBL14769351 | 0.80 | RAB9A (0.66) | RAB9AMEN1KMT2AMAPTPOLB | |
| SCHEMBL12328428 | 0.79 | MAPT (0.74) | RAB9AMEN1KMT2AMAPTPOLB | |
| SCHEMBL12008798 | 0.78 | KMT2A (0.77) | RAB9AMEN1KMT2AMAPTPOLB | |
| SCHEMBL12008787 | 0.78 | KMT2A (0.76) | RAB9AMEN1KMT2AMAPTPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9101600-B2 | Compounds as RORγt modulators and uses thereof | NEW YORK UNIVERSITY (US) | 2015-08-11 | — | — | US | disclosed |
| US-9101600-B2 | Compounds as RORγt modulators and uses thereof | NEW YORK UNIVERSITY (US) | 2015-08-11 | — | — | US | disclosed |