Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 10/20 | 0.74 |
| ▸ | POLB | P06746 | 5/20 | 0.74 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.74 |
| ▸ | PTPN7 | P35236 | 2/20 | 0.74 |
| ▸ | PTPN12 | Q05209 | 2/20 | 0.74 |
| ▸ | GPR35 | Q9HC97 | 2/20 | 0.74 |
| ▸ | PTPN22 | Q9Y2R2 | 2/20 | 0.74 |
| ▸ | PLA2G1B | P04054 | 2/20 | 0.74 |
| ▸ | ATG4B | Q9Y4P1 | 2/20 | 0.74 |
| ▸ | LMNA | P02545 | 2/20 | 0.74 |
| ▸ | GAA | P10253 | 2/20 | 0.74 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.74 |
| ▸ | NPC1 | O15118 | 2/20 | 0.69 |
| ▸ | ATM | Q13315 | 1/20 | 0.69 |
| ▸ | KMT2A | Q03164 | 10/20 | 0.69 |
| ▸ | MEN1 | O00255 | 9/20 | 0.69 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.69 |
| ▸ | RAB9A | P51151 | 3/20 | 0.69 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.69 |
| ▸ | TP53 | P04637 | 1/20 | 0.69 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12328427 | 0.90 | KMT2A (0.76) | MAPTPOLBALDH1A1PTPN7PTPN12 | |
| SCHEMBL17240993 | 0.82 | KMT2A (1.00) | MAPTPOLBALDH1A1PTPN7PTPN12 | |
| SCHEMBL17240991 | 0.82 | KMT2A (1.00) | MAPTPOLBALDH1A1PTPN7PTPN12 | |
| SCHEMBL16994217 | 0.79 | RAB9A (1.00) | MAPTPOLBALDH1A1PLA2G1BATG4B | |
| SCHEMBL12008983 | 0.79 | POLB (1.00) | MAPTPOLBALDH1A1LMNAGAA | |
| SCHEMBL13417308 | 0.77 | KMT2A (1.00) | MAPTPOLBALDH1A1PTPN7PTPN12 | |
| SCHEMBL12328425 | 0.74 | MAPT (0.84) | MAPTPOLBALDH1A1PTPN7PTPN12 | |
| SCHEMBL12008878 | 0.73 | POLB (0.90) | MAPTPOLBLMNANPC1KMT2A | |
| Epalrestat SCHEMBL49049 | 0.73 | MAPT (1.00) | MAPTPOLBALDH1A1PTPN7PTPN12 | |
| Epalrestat SCHEMBL6679566 | 0.73 | MAPT (1.00) | MAPTPOLBALDH1A1PTPN7PTPN12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8906937-B2 | Flavivirus inhibitors and methods of their use | GEORGETOWN UNIVERSITY (US) | 2014-12-09 | — | — | US | disclosed |
| US-20140038962-A1 | Flavivirus Inhibitors and Methods of Their Use | GEORGETOWN UNIVERSITY (US) | 2014-02-06 | — | — | US | disclosed |
| US-8563580-B2 | Flavivirus inhibitors and methods for their use | GEORGETOWN UNIVERSITY (US) | 2013-10-22 | — | — | US | disclosed |
| US-20110224207-A1 | FLAVIVIRUS INHIBITORS AND METHODS FOR THEIR USE | GEORGETOWN UNIVERSITY (US) | 2011-09-15 | — | — | US | disclosed |
| WO-2010039538-A2 | FLAVIVIRUS INHIBITORS AND METHODS FOR THEIR USE | GEORGETOWN UNIVERSITY (US) | 2010-04-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110224207-A1 | FLAVIVIRUS INHIBITORS AND METHODS FOR THEIR USE | SERPINB1, SPINT2, MME | MAPT 1317/4885POLB 3870/4885ALDH1A1 1498/4885 |
| US-20140038962-A1 | Flavivirus Inhibitors and Methods of Their Use | SERPINB1, SPINT2, MME | MAPT 1488/4885POLB 3460/4885ALDH1A1 1625/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.