Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 14/20 | 0.70 |
| ▸ | PTK2 | Q05397 | 6/20 | 0.54 |
| ▸ | TTK | P33981 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12065489 | 0.83 | LRRK2 (1.00) | LRRK2PTK2TTK | |
| SCHEMBL1611693 | 0.81 | LRRK2 (0.68) | LRRK2PTK2 | |
| SCHEMBL13191369 | 0.80 | LRRK2 (0.81) | LRRK2PTK2 | |
| SCHEMBL16995419 | 0.78 | PTK2 (0.53) | LRRK2PTK2TTK | |
| SCHEMBL20430689 | 0.78 | PTK2 (0.85) | PTK2 | |
| SCHEMBL30680146 | 0.75 | LRRK2 (0.76) | LRRK2TTK | |
| SCHEMBL21761352 | 0.75 | LRRK2 (0.76) | LRRK2TTK | |
| SCHEMBL21855436 | 0.75 | LRRK2 (0.76) | LRRK2TTK | |
| SCHEMBL7458679 | 0.74 | LRRK2 (1.00) | LRRK2TTK | |
| SCHEMBL14556239 | 0.74 | LRRK2 (0.75) | LRRK2PTK2TTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2408752-B1 | SUBSTITUTED PYRIMIDINES FOR THE TREATMENT OF CANCER | BOEHRINGER INGELHEIM INT (DE) | 2015-08-12 | — | — | EP | disclosed |